1098-92-6Relevant articles and documents
Total synthesis of kaempferol and methylated kaempferol derivatives
Lee, Yean-Jang,Wu, Tsao-Dong
, p. 201 - 206 (2001)
Kaempferol (1), a natural product from various plants, was synthesized in which the longest linear sequence is only seven steps in overall yields of 47% from commercially available 1,3,5-trimethoxybenzene (10). The methylated kaempferols 2-5 were also prepared by use of this concise synthetic methodology. The key transformations in this synthesis involved the I2 oxidative-promoting-cyclization and DDO oxidative hydroxylation. Several strategies to achieve 1 are provided.
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Furuya,Galston
, p. 285,290-292 (1965)
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Flavonol glycosides from Cassia hirsuta
Rao,Damu,Jayaprakasam,Gunasekar
, p. 305 - 306 (1999)
A new flavonol glycoside, kaempferol 3-O-α-L-rhamnopyranosyl (1→2)- α-L-rhamnopyranoside (1), was isolated from the flowers of Cassia hirsuta along with two known flavonol glycosides, kaempferol 3-O-rutinoside and rutin. The structure of compound 1 has been established on the basis of spectral data and by acid hydrolysis.
MASS SPECTROMETRY IN THE STRUCTURAL DETERMINATION OF FLAVONOL TRIGLYCOSIDES FROM VINCA MAJOR
Sakushima, Akiyo,Nishibe, Sansei
, p. 915 - 920 (1988)
Key Word Index-Vinca major; Apocynaceae; leaves; flavonol glycosides; kaempferol 3-O-(6''-O-rhamnosyl)-galactosides 7-O-glucoside; chlorogenic acid; mass spectrometry.Chlorogenic acid, robinin and flavonol triglycoside were isolated from the leaves of Vinca major.The structure of the triglycoside was determined to be kaempferol 3-O-(6''-rhamnopyranosyl)-galactopyranoside 7-O-glucopyranoside by fast atom bombardment, electron impact and negative ion desorption chemical ionization mass spectropetry.
1-deoxynojirimycin-kaempferol compound, intermediate, preparation method and application
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Paragraph 0037; 0040; 0048-0053, (2020/12/31)
The invention discloses a 1-deoxynojirimycin-kaempferol compound, an intermediate, a preparation method and application. The structural formula of the compound is as shown in the specification. In thestructural formula, R is -CnH2n-, n is an integer, and
Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors
Zhang, Wenhan,Chu, Jennifer,Cyr, Andrew M.,Yueh, Han,Brown, Lauren E.,Wang, Tony T.,Pelletier, Jerry,Porco, John A.
, p. 12891 - 12900 (2019/09/09)
Rocaglates are a family of natural products isolated from the genus Aglaia which possess a highly substituted cyclopenta[b]benzofuran skeleton and inhibit cap-dependent protein synthesis. Rocaglates are attractive compounds due to their potential for inhibiting tumor cell maintenance in vivo by specifically targeting eukaryotic initiation factor 4A (eIF4A) and interfering with recruitment of ribosomes to mRNA. In this paper, we describe an intercepted retro-Nazarov reaction utilizing intramolecular tosyl migration to generate a reactive oxyallyl cation on the rocaglate skeleton. Trapping of the oxyallyl cation with a diverse range of nucleophiles has been used to generate over 50 novel amidino-rocaglate (ADR) and amino-rocaglate derivatives. Subsequently, these derivatives were evaluated for their ability to inhibit cap-dependent protein synthesis where they were found to outperform previous lead compounds including the rocaglate hydroxamate CR-1-31-B.