11000-17-2

Basic information

• Product Name: Vasopressin
• Synonyms: adh(hormone);leiormone;pitressin;pituitrin;tonephin;vasophysin;1-[19-amino-13-butan-2-yl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-(carbamoylmethylcarbamoyl)-4-(diaminomethylideneamino)butyl]pyrrolidine-2-carboxamide;VASOPRESSIN ACETATE
• CAS NO: 11000-17-2
• Molecular Formula: C46H65N13O12S2
• Molecular Weight: 1056.22
• EINECS: 200-050-5
• Mol File: 11000-17-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1610.4 °C at 760 mmHg
• Flash Point: 927.7 °C
• Appearance: White/Lyophilized Powder
• Density: 1.31 g/cm³
• Water Solubility: Soluble in water (Miscible).
• CAS DataBase Reference: Vasopressin(CAS DataBase Reference)
• NIST Chemistry Reference: Vasopressin(11000-17-2)
• EPA Substance Registry System: Vasopressin(11000-17-2)

Safety Data

• Hazardous Substances Data: 11000-17-2(Hazardous Substances Data)

Usage

Description

Vasopressin, also known as antidiuretic hormone (ADH), is a peptide hormone that plays a crucial role in regulating the body's water balance. It is synthesized in the hypothalamus and released by the posterior pituitary gland. Vasopressin helps control the amount of water reabsorbed by the kidneys, thereby maintaining the body's fluid and electrolyte balance.

Uses

Used in Medical Applications:
Vasopressin is used as a medication for treating conditions related to fluid and electrolyte imbalances, such as diabetes insipidus and hyponatremia. It helps to reduce excessive urination and increase water reabsorption in the kidneys, thus correcting the imbalance.
Used in Emergency Medicine:
In emergency medicine, vasopressin is used as a vasoconstrictor to treat severe hypotension (low blood pressure) that is unresponsive to other treatments. Its ability to constrict blood vessels helps to raise blood pressure and improve blood flow to vital organs.
Used in Cardiology:
Vasopressin is used in cardiology for the treatment of certain arrhythmias (irregular heartbeats) and as an adjunct therapy in cardiac arrest situations. Its vasoconstrictive properties can help stabilize blood pressure and improve the chances of successful resuscitation.
Used in Nephrology:
In nephrology, vasopressin is used to manage patients with acute kidney injury or chronic kidney disease who experience fluid and electrolyte imbalances. It helps to regulate the body's water retention and maintain proper kidney function.
Used in Endocrinology:
Vasopressin plays a role in endocrinology for the management of conditions such as syndrome of inappropriate antidiuretic hormone secretion (SIADH), where the body produces too much antidiuretic hormone, leading to hyponatremia. Vasopressin antagonists can be used to counteract the effects of excess ADH and restore normal electrolyte balance.

Veterinary Drugs and Treatments

Vasopressin is used in veterinary medicine as a diagnostic agent and in the treatment of diabetes insipidus in small animals. In recent years, there has been significant interest in using vasopressin for treating shock syndromes in humans and animals. Ongoing research is being conducted. In human medicine, vasopressin has been used to treat acute GI hemorrhage and to stimulate GI peristalsis. Vasopressin CRI is also being used for treatment of hypotensive septic patients unresponsive to conventional vasopressor. Prior to radiographic procedures, it has been used to dispel interfering gas shadows or help concentrate contrast media.

InChI:InChI=1/C43H67N15O12S2/c1-3-21(2)34-41(69)53-26(12-13-31(45)60)37(65)55-28(17-32(46)61)38(66)56-29(20-72-71-19-24(44)35(63)54-27(39(67)57-34)16-22-8-10-23(59)11-9-22)42(70)58-15-5-7-30(58)40(68)52-25(6-4-14-50-43(48)49)36(64)51-18-33(47)62/h8-11,21,24-30,34,59H,3-7,12-20,44H2,1-2H3,(H2,45,60)(H2,46,61)(H2,47,62)(H,51,64)(H,52,68)(H,53,69)(H,54,63)(H,55,65)(H,56,66)(H,57,67)(H4,48,49,50)