11050-94-5 Usage
Description
Oligomycin B, a component of the oligomycin complex isolated from selected strains of Streptomyces, is a macrolide that acts as a nonselective inhibitor of mitochondrial F1F0-ATPase. It is highly specific for the disruption of mitochondrial metabolism and can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.
Uses
Used in Pharmaceutical Industry:
Oligomycin B is used as an antibiotic for its ability to inhibit ATP synthase, making cells more susceptible to cell death and leading to a switch in the death mode from apoptosis to necrosis.
Used in Research Applications:
Oligomycin B is used as a research tool to study the effects of mitochondrial F1FO ATP synthase inhibition on cellular processes and to investigate its potential role in the treatment of various diseases.
in vitro
previous study found that oligomycin b and aurovertin b were able to inhibit both the synthase and the hydrolase function, which not only rendered them difficult to be experimentally used, but also precluded them from being therapeutics. aurovertin b bound between the subunits catalytic f1 domain of the f1f0 atpase, where it prevented the conformational changes required for the catalytic cycle of this enzyme, whereas oligomycin bound to the f0 domain and blocked proton flow [1].
in vivo
in a previous animal study, intracranial pressure measurements were performed in sd rats treated by intraperitoneal injection of vehicle, cyclosporine a, or oligomycin b. it was found that cerebral edema and mitochondrial impairment could be significantly worsened by treatment with oligomycin b, whereas a noticeable improvement could be observed in animals that received injections of cyclosporine a [2].
references
[1] g. j. grover and j. malm. pharmacological profile of the selective mitochondrial f1f0 atp hydrolase inhibitor bms-199264 in myocardial ischemia. cardiovasc.ther. 26, 287-296 (2008).[2] vlodavsky e, palzur e, shehadeh m, soustiel jf. post-traumatic cytotoxic edema is directly related to mitochondrial function. j cereb blood flow metab. 2017 jan;37(1):166-177.
Check Digit Verification of cas no
The CAS Registry Mumber 11050-94-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,5 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 11050-94:
(7*1)+(6*1)+(5*0)+(4*5)+(3*0)+(2*9)+(1*4)=55
55 % 10 = 5
So 11050-94-5 is a valid CAS Registry Number.
InChI:InChI=1/C45H72O12/c1-12-33-17-15-13-14-16-25(3)42(52)44(11,54)43(53)31(9)40(51)30(8)39(50)29(7)38(49)24(2)18-21-37(48)55-41-28(6)34(20-19-33)56-45(32(41)10)36(47)22-26(4)35(57-45)23-27(5)46/h13-15,17-18,21,24-35,38,40-42,46,49,51-52,54H,12,16,19-20,22-23H2,1-11H3/b14-13-,17-15+,21-18+/t24-,25+,26-,27+,28+,29-,30-,31-,32-,33-,34-,35-,38+,40+,41+,42-,44+,45+/m1/s1