1109276-87-0Relevant articles and documents
Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1
Dow, Robert L.,Li, Jian-Cheng,Pence, Michael P.,Gibbs, E. Michael,Laperle, Jennifer L.,Litchfield, John,Piotrowski, David W.,Munchhof, Michael J.,Manion, Tara B.,Zavadoski, William J.,Walker, Gregory S.,McPherson, R. Kirk,Tapley, Susan,Sugarman, Eliot,Guzman-Perez, Angel,Dasilva-Jardine, Paul
scheme or table, p. 407 - 412 (2011/07/08)
Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides. DGAT-1 knockout mice have been shown to be resistant to diet-induced obesity and have increased insulin sensitivity. Thus, inhibiti
SUBSTITUTED BICYCLOLACTAM COMPOUNDS
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Page/Page column 18, (2009/03/07)
The invention provides compounds of formula (1), and the pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5a, R5b, R5c, R5d, Q, A, Z, and R7 /s