112366-49-1 Usage
Molecular Weight
344.19 g/mol This is the mass of one mole of the compound, calculated by adding the atomic weights of all the atoms in the formula.
Structure
1H-Imidazole-5-carboxylic acid, 1-[1-(2-bromophenyl)ethyl]-, ethyl ester, (R)This is a description of the compound's structure, indicating the arrangement of atoms and the type of bonding.
Class
Imidazole carboxylic acid derivatives This indicates the functional group and chemical class to which the compound belongs.
Type
Ethyl ester derivative This indicates the specific type of derivative of the parent compound.
Enantiomer Configuration
(R)This indicates the three-dimensional shape and configuration of the molecule, which can affect its properties and interactions with other compounds.
Usage
Building block in organic synthesis and pharmaceutical research This indicates the common applications of the compound in the field of chemistry and drug development.
Value
Unique structure and properties This highlights the compound's distinctive features that make it valuable in the development of potential therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 112366-49-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,3,6 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 112366-49:
(8*1)+(7*1)+(6*2)+(5*3)+(4*6)+(3*6)+(2*4)+(1*9)=101
101 % 10 = 1
So 112366-49-1 is a valid CAS Registry Number.
112366-49-1Relevant articles and documents
Synthesis of fused imidazoles, pyrroles, and indoles with a defined stereocenter α to nitrogen utilizing mitsunobu alkylation followed by palladium-catalyzed cyclization
Laha, Joydev K.,Cuny, Gregory D.
, p. 8477 - 8482 (2011)
Nitrogen-containing fused heterocycles comprise many compounds that demonstrate interesting biological activities. A new synthetic approach involving Mitsunobu alkylation of imidazoles, pyrroles, and indoles followed by palladium-catalyzed cyclization has been developed providing access to fused heterocycles with a defined stereochemistry α to nitrogen. While ethyl imidazole or indole carboxylates are good substrates for Mitsunobu alkylation with optically pure secondary benzylic alcohols, the corresponding pyrroles are poor substrates presumably due to the increased pKa of the NH. The presence of a synthetically versatile trichloroacetyl functional group on the pyrroles significantly reduces the pKa and thereby facilitates Mitsunobu alkylation. Subsequent cyclization of the alkylated products mediated by palladium in the presence or absence of a ligand gave fused heterocycles in good to excellent yields.
