112638-27-4Relevant articles and documents
NEW CHIRAL BUILDING BLOCKS BY MICROBIAL ASYMMETRIC REDUCTION: A DIRECT ACCESS TO FUNCTIONALIZED 2R,3R- AND 2S,3R-2-METHYL-3-HYDROXY BUTYRATE SYNTHONS
Buisson, Didier,Henrot, Serge,Larcheveque, Marc,Azerad, Robert
, p. 5033 - 5036 (2007/10/02)
The reduction of 4-O-benzyl-2-methyl-3-oxo-butyrate esters by several fungal strains produces predominantly (2S,3R)-anti-hydroxyesters in high optical purity.The corresponding (2R,3R)-syn isomer was obtained, with other strains, only in mixture with the anti isomer.These esters are useful precursors for chiral 2-methyl-3-hydroxy-butyrolactone synthons.