112830-95-2

Basic information

• Product Name: HU-210
• Synonyms: HU-210 DEA Schedule I;(6aR)-trans-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-(6H)-dibenzo[b.d]pyran-9-methanol;(-)-11-OH-Δ8-THC-1,1-dimethylheptyl;(6aR)-6aβ,7,10,10aα-Tetrahydro-1-hydroxy-6,6-dimethyl-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol;(6aR)-6aβ,7,10,10aα-Tetrahydro-6,6-dimethyl-1-hydroxy-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol;[6aR,(-)]-6a,7,10,10aα-Tetrahydro-1-hydroxy-6,6-dimethyl-3-(1,1-dimethylheptyl)-6H-dibenzo[b,d]pyran-9-methanol;11-OH-Δ8-THC-1,1-dimethylheptyl;(6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
• CAS NO: 112830-95-2
• Molecular Formula: C₂₅H₃₈O₃
• Molecular Weight: 386.57
• EINECS: 200-659-6
• Product Categories: Cannabinoid receptor;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 112830-95-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 470.1°Cat760mmHg
• Flash Point: 9℃
• Appearance: /solid
• Density: 1.03g/cm³
• Vapor Pressure: 6.93E-10mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: −20°C
• Solubility: DMSO: soluble
• PKA: 9.72±0.60(Predicted)
• BRN: 4298162
• CAS DataBase Reference: HU-210(CAS DataBase Reference)
• NIST Chemistry Reference: HU-210(112830-95-2)
• EPA Substance Registry System: HU-210(112830-95-2)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• Hazardous Substances Data: 112830-95-2(Hazardous Substances Data)

Usage

Description

HU-210, also known as T293200, is a synthetic agonist analog of Δ9-Tetrahydrocannabinol (THC), the primary psychoactive component of marijuana. It is a potent central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist, binding to neuroblastoma cell membrane CB1 receptors with similar affinity as CP-55940. HU-210 is a liquid and is regulated as a Schedule I compound in the United States, with its exempt preparation intended for research and forensic applications.

Uses

Used in Pharmaceutical Research:
HU-210 is used as a research compound for studying the effects and mechanisms of action of cannabinoids on the central and peripheral cannabinoid receptors. Its potent agonist properties make it a valuable tool in understanding the therapeutic potential of cannabinoids in various medical conditions.
Used in Forensic Applications:
HU-210 is used as an analytical reference standard in forensic analysis to identify and quantify the presence of synthetic cannabinoids in biological samples, such as blood, urine, or tissue. This helps in the investigation of drug-related crimes and the assessment of drug abuse patterns.
Used in Drug Development:
HU-210 serves as a starting point for the development of new drugs with improved safety, efficacy, and pharmacokinetic profiles. By studying its interactions with cannabinoid receptors, researchers can design novel compounds with targeted therapeutic effects and reduced side effects.
Used in Toxicological Studies:
HU-210 is used in toxicological research to evaluate the safety and potential risks associated with synthetic cannabinoids. This helps in understanding the toxic effects of these compounds and establishing safety guidelines for their use in medical and recreational settings.

Biological Activity

A highly potent cannabinoid receptor agonist (K i values are 0.061 and 0.52 nM at cloned human CB 1 and CB 2 receptors respectively). Induces spatial memory deficits and suppresses hippocampal firing rates in rats. Also displays agonist activity at GPR55 (EC 50 = 26 nM). Also available as part of the Cannabinoid Receptor Agonist Tocriset? .

InChI:InChI=1/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h13-15,19-20,26-27H,6-12,16H2,1-5H3/t19-,20-/m0/s1

Upstream product

• 76163-95-6 (1R,5S)-2-[(2,2-dimethylpropoyloxy)methyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene 
• 76163-97-8 2,2-Dimethyl-propionic acid (1R,5R)-4-hydroxy-6,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-ylmethyl ester 
• 76163-96-7 2,2-Dimethyl-propionic acid (1R,5R)-6,6-dimethyl-4-oxo-bicyclo[3.1.1]hept-2-en-2-ylmethyl ester 
• 19894-97-4 (1R)-Myrtenol 
• 56469-10-4 5-(1',1'-dimethyl-n-heptyl)-1,3-dihydroxybenzene 
• 113418-02-3 2,2-Dimethyl-propionic acid (6aR,10aR)-3-(1,1-dimethyl-heptyl)-1-hydroxy-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-9-ylmethyl ester 

Downstream Products

• 140835-14-9 [3H]-HU 243 

Related news

Cannabinoids & Stress: Impact of HU-210 (cas 112830-95-2) on behavioral tests of anxiety in acutely stressed mice07/24/2019

Anxiety disorders are one of the most prevalent classes of mental disorders affecting the general population, but current treatment strategies are restricted by their limited efficacy and side effect profiles. Although the cannabinoid system is speculated to be a key player in the modulation of ...detailed

Relevant articles and documents

SYNTHESIS OF THE INDIVIDUAL, PHARMACOLOGICALLY DISTINCT, ENANTIOMERS OF A TETRAHYDROCANNABINOL DERIVATIVE

The individual enantiomers of the 1,1-dimethylheptyl homolog of 7-hydroxy-Δ6-tetrahydrocannabinol, (1) and (2a), which exhibit distinct pharmacological profiles, have been obtained with very high e.e. by synthesis from the antipodes of myrtenol.