114-83-0 Usage
Description
1-Acetyl-2-phenylhydrazine is a colorless prism or white solid that exists as a white to light yellow crystal powder. It is an organic compound with the chemical properties of a white to light yellow crystalline powder.
Uses
1. Used in Chemical Synthesis:
1-Acetyl-2-phenylhydrazine is used as an intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries. Its unique structure allows it to be a versatile building block for the creation of a wide range of products.
2. Used in Anaerobic Curing Applications:
1-Acetyl-2-phenylhydrazine is used as an anaerobically curable compound, which means it can be used in the production of materials that cure or harden in the absence of oxygen. This property makes it suitable for applications such as adhesives, sealants, and coatings that require airtight or watertight seals.
3. Used in Pharmaceutical Industry:
1-Acetyl-2-phenylhydrazine is used as a key component in the development of pharmaceuticals, particularly in the synthesis of drugs that target specific biological pathways. Its reactivity and structural diversity make it a valuable compound for medicinal chemistry research and drug discovery.
4. Used in Research and Development:
Due to its unique chemical properties, 1-Acetyl-2-phenylhydrazine is used in research and development for the exploration of new chemical reactions, synthesis methods, and potential applications in various industries, including materials science, electronics, and biotechnology.
Synthesis Reference(s)
The Journal of Organic Chemistry, 30, p. 2486, 1965 DOI: 10.1021/jo01018a525
Air & Water Reactions
Water insoluble.
Reactivity Profile
1-Acetyl-2-phenylhydrazine is an amide and an amine. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 1-Acetyl-2-phenylhydrazine emits toxic fumes.
Fire Hazard
Flash point data for 1-Acetyl-2-phenylhydrazine are not available. 1-Acetyl-2-phenylhydrazine is probably combustible.
Purification Methods
Crystallise the hydrazine from aqueous EtOH. [Beilstein 15 H 241.]
Check Digit Verification of cas no
The CAS Registry Mumber 114-83-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 114-83:
(5*1)+(4*1)+(3*4)+(2*8)+(1*3)=40
40 % 10 = 0
So 114-83-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2.C2H4O2/c7-8-6-4-2-1-3-5-6;1-2(3)4/h1-5,8H,7H2;1H3,(H,3,4)
114-83-0Relevant articles and documents
A formal [3+2] cycloaddition reaction of: N -methylimidazole as a masked hydrogen cyanide: Access to 1,3-disubstitued-1 H -1,2,4-triazoles
Yavari, Issa,Khaledian, Omid
supporting information, p. 9150 - 9153 (2020/10/02)
N-Methylimidazole (NMI) can act as a masked HCN in the synthesis of 1,3-disubstitued-1H-1,2,4-triazoles via a formal cycloaddition reaction of hydrazonoyl chloride with NMI. The product was proved to be formed via an initial nucleophilic substitution of hydrazonoyl chloride with NMI following cyclization and two sequential C-N bond cleavages. This journal is
A magnetically recoverable copper–salen complex as a nano-catalytic system for amine protection via acetylation using thioacetic acid
Yazdani, Elahe,Kazemi Miraki, Maryam,Salamatmanesh, Arefe,Azarnia, Jamshid,Azizi, Kobra,Ghandi, Leila,Heydari, Akbar
, p. 1775 - 1793 (2019/01/16)
A novel copper(II)–salen complex was immobilized on the surface of magnetite nanoparticles using chitosan as a linker. This system exhibits superior catalytic activity in acetyl protection of various amines with thioacetic acid as the acetylating reagent. The method has advantages over others in high selectivity, simple work-up, green reaction medium and the application of an easily recoverable heterogeneous catalyst.
Synthesis method for organic synthesis of intermediate acetyl phenylhydrazine
-
Paragraph 0011; 0013; 0014; 0015, (2018/07/30)
The invention relates to a synthesis method for organic synthesis of an intermediate acetyl phenylhydrazine. The method mainly includes the steps of: adding 3mol phenylhydrazine into a reaction container and 4-5mol p-iodoacetanilide into a reaction container, performing heating to 90-95DEG C, conducting reflux for 130-150min, lowering temperature to 10-15DEG C, filtering the crystal, conducting washing with a methylamine solution and a dichloromethane solution respectively, performing recrystallization in an ethanol solution, precipitating crystals, conducting filtration, and performing dehydration with a dehydrating agent, thus obtaining the finished product acetyl phenylhydrazine.