114973-02-3Relevant articles and documents
Enantioselective total synthesis of (+)-peniciketals A and B: Two architecturally complex spiroketals
Deng, Yifan,Smith, Amos B.,Yang, Chia-Ping H.
, p. 1740 - 1744 (2021/02/16)
The enantioselective total syntheses of (+)-peniciketals A and B, two members of a family of architecturally complex spiroketals, have been achieved. Key synthetic transformations comprise Type I Anion Relay Chemistry (ARC) to construct the benzannulated [6,6]-spiroketal skeleton, a Negishi cross-coupling/olefin cross-metathesis reaction sequence to generate the trans-enone structure, and a late-stage large fragment union exploiting our recently developed photoisomerization/cyclization tactic.
