1150635-61-2Relevant articles and documents
A Scalable Total Synthesis of the Antitumor Agents Et-743 and Lurbinectedin
He, Weiming,Zhang, Zhigao,Ma, Dawei
supporting information, p. 3972 - 3975 (2019/02/24)
An efficient and scalable approach is described for the total synthesis of the marine natural product Et-743 and its derivative lubinectedin, which are valuable antitumor compounds. The method delivers 1.6 % overall yield in 26 total steps from Cbz-protected (S)-tyrosine. It features the use of a common advanced intermediate to create the right and left parts of these compounds, and a light-mediated remote C?H bond activation to assemble a benzo[1,3]dioxole-containing intermediate.
A new approach to the synthesis of l-3-hydroxy-4-methoxy-5-methyl-phenylalanine derivatives from l-tyrosine
Chen, Ruijiao,Zhu, Deguang,Hu, Zuoqiang,Zheng, Zhiming,Chen, Xiaochuan
experimental part, p. 39 - 42 (2010/04/24)
A practical procedure to regioselectively install a methyl group and a phenolic hydroxyl group onto l-tyrosine was developed. By using this approach, protected l-3-hydroxy-4-methoxy-5-methyl-phenylalanine and l-3-hydroxy-4-methoxy-5-methyl-phenylalanol, which are utilized in efficient syntheses of the relevant tetrahydroisoquinoline alkaloids, were prepared conveniently with high yield.
