1159824-67-5

Basic information

• Product Name: CZC24832
• Synonyms: CZC24832;5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(tert-butyl)-3-pyridinesulfonamide;3-Pyridinesulfonamide, 5-(2-amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-;5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(tert-butyl)-3-pyridinesulfonamide CZC 24832;CZC 24832 5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(tert-butyl)-3-pyridinesulfonamide
• CAS NO: 1159824-67-5
• Molecular Formula: C15H17FN6O2S
• Molecular Weight: 364.3978832
• EINECS: 200-258-5
• Product Categories: PI3K/Akt/mTOR;Inhibitors;Akt;mTOR;PI3K
• Mol File: 1159824-67-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.51
• Solubility: insoluble in H2O; insoluble in EtOH; ≥6.07 mg/mL in DMSO with gentle warming
• PKA: 10.29±0.50(Predicted)
• CAS DataBase Reference: CZC24832(CAS DataBase Reference)
• NIST Chemistry Reference: CZC24832(1159824-67-5)
• EPA Substance Registry System: CZC24832(1159824-67-5)

Safety Data

• Hazardous Substances Data: 1159824-67-5(Hazardous Substances Data)

Usage

Description

CZC24832 is a selective phosphoinositide 3-kinase γ (PI3Kγ) inhibitor, which plays a crucial role in regulating the differentiation of interleukin-17-producing T helper cells (TH17) through the PI3Kγ pathway. This characteristic makes CZC24832 a promising compound for the treatment of various inflammatory and autoimmune diseases.

Uses

Used in Pharmaceutical Industry:
CZC24832 is used as a potential treatment for inflammatory and autoimmune diseases due to its ability to regulate TH17 cell differentiation by inhibiting PI3Kγ. This selective inhibition can help in managing the immune response and reducing inflammation associated with these conditions.
Used in Research and Development:
CZC24832 is also used as a research tool for studying the role of PI3Kγ in immune cell signaling and the development of TH17 cells. This can contribute to a better understanding of the underlying mechanisms of inflammatory and autoimmune diseases, leading to the development of novel therapeutic strategies.

Relevant articles and documents

SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors

Herein we describe the SAR of a novel series of 6-aryl-2-amino- triazolopyridines as potent and selective PI3Kγ inhibitors. The 6-aryl-triazolopyridine core was identified by chemoproteomic screening of a kinase focused library. Rapid chemical expansion a

AMINO TRIAZOLES AS PI3K INHIBITORS

The invention relates to compounds of formula (I) Said compounds are useful as protein kinase inhibitors, especially inhibitors of P13K, for the treatment or prophylaxis of immunological, inflammatory, autoimmune, or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.