1163128-59-3Relevant articles and documents
Synthesis and characterization of potential pharmacopeial impurities of oseltamivir: An antiviral drug
Ponduri, Rajasekhar,Kumar, Pramod,Vadali, Lakshmana Rao,Aelugu, Komaraiah,Matcha, Kishore
, p. 2003 - 2007 (2018)
Impurities of oseltamivir phosphate were synthesized from chiral epoxide (1) in a simpler and much feasible synthetic approach in seven steps accounting to 8.2 % overall yield. The nucleophilic addition of N3 (highly regioselective and stereoselective) in
METHOD OF FORMING OSELTAMIVIR AND DERIVATIVES THEREOF
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Page/Page column 42, (2009/07/18)
A process is provided for the synthesis of 4,5-diamino cyclohexene carboxylate ester (1): or a pharmaceutically acceptable salt thereof. R1 - R3 are a silyl-, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. R4, R11 and R12 are H, a silyl-group, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. 3,4-Dihydropyran compound (9): with R5 and R6 being suitable protecting groups, is reacted to form aldehyde (4): which is oxidized and converted to N-substituted carbamate (3): with R7 being a suitable protecting group. (3) is, via oxazolinidone (13): converted to azido carboxylate ester (2): and then to 4,5-diamino cyclohexene carboxylate ester (1).