116526-34-2

Basic information

• Product Name: 3-(4-METHOXYPHENYL)CYCLOPENTANONE
• Synonyms: 3-(4-METHOXYPHENYL)CYCLOPENTANONE
• CAS NO: 116526-34-2
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.24
• Mol File: 116526-34-2.mol
• Article Data: 18

Chemical Properties

• Melting Point: 47-49 °C
• Boiling Point: 319.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.097±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-(4-METHOXYPHENYL)CYCLOPENTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXYPHENYL)CYCLOPENTANONE(116526-34-2)
• EPA Substance Registry System: 3-(4-METHOXYPHENYL)CYCLOPENTANONE(116526-34-2)

Safety Data

• Hazardous Substances Data: 116526-34-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 2111, 1988 DOI: 10.1016/S0040-4039(00)87848-X

Upstream product

• 57769-42-3 4-(2,3-epoxy-cyclopentyl)-anisole 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 2108-53-4 3-(4-Methoxyphenyl)-2-cyclopenten-1-one 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 930-30-3 cyclopent-2-enone 
• 1120-73-6 2-methyl-2-cyclopenten-1-one 
• 696-62-8 para-iodoanisole 
• 132610-17-4 1-<2-bis(methylthio)methyleneacetyl>-2-(4-methoxyphenyl)cyclopropane 
• 70106-27-3 2-(4-methoxyphenyl)cyclobutan-1-one 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 5720-07-0 4-methoxyphenylboronic acid 
• 22627-70-9 3-ethoxycyclopent-2-en-1-one 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 89812-52-2 (E)-5-(4-methoxyphenyl)-1,1-bis(methylthio)-penta-1,4-dien-3-one 

Downstream Products

• 1267388-03-3 3-(4-methoxyphenyl)cyclopentanol 
• 129852-17-1 {3-[4-(Quinolin-2-ylmethoxy)-phenyl]-cyclopentyl}-acetic acid methyl ester 
• 304024-20-2 {3-[4-(Quinolin-2-ylmethoxy)-phenyl]-cyclopentyl}-acetic acid 
• 129650-13-1 1-<(methoxycarbonyl)methyl>-3-(4-hydroxyphenyl)cyclopentane 
• 148915-87-1 1-formyl-3-(4-methoxyphenyl)cyclopentane diethyl acetal 
• 118298-40-1 3-(4-methoxyphenyl)cyclopentane-1,1-dicarboxylic acid 
• 190064-52-9 3-(4-methoxyphenyl)cyclopentanecarboxaldehyde 
• 190064-51-8 1-methoxy-4-(3-methoxymethylenecyclopentyl) benzene 
• 129650-12-0 1-<(methoxycarbonyl)methylene>-3-(4-methoxyphenyl)cyclopentane 
• 129650-14-2 3-(4-methoxyphenyl)cyclopentenenitrile 
• 129650-15-3 3-(4-methoxyphenyl)cyclopentenenitrile 

Relevant articles and documents

BCL-2 INHIBITOR

Disclosed herein is a compound of Formula (I) for inhibiting both Bcl-2 wild type and mutated Bcl-2, in particular, Bcl-2 G101V and D103Y, and a method of using the compound disclosed herein for treating dysregulated apoptotic diseases.

4,8-disubstituted bicyclo[3.3.1]nona-2,6-dienes as chiral ligands for rh-catalyzed asymmetric 1,4-addition reactions

C2-symmetric chiral diene ligands based on 4,8-endo,endo-disubstituted bicyclo[3.3.1]nona-2,6-diene framework have been designed and synthesized. The rhodium complexes of the dienes, which were obtained in a few straightforward steps from enantiomerically pure bicyclo[3.3.1]nonane-2,6-dione, exhibited excellent catalytic activity and high enantioselectivity (up to 96% ee) in the conjugate addition reaction of arylboronic acids to cyclic enones under mild reaction conditions with high atom efficiency. Chiral C2-symmetric 4,8-endo,endo-disubstituted bicyclo[3.3.1]nona-2,6-diene ligands were synthesized from easily available bicyclo[3.3.1]nonane-2,6-dione and utilized in the asymmetric 1,4-addition reaction of arylboronic acids to cyclic enones. The catalyst prepared in situ from ligand 4b and [RhCl(C2H4)2]2 exhibited excellent catalytic activity and high enantioselectivity (up to 96% ee) under mild reaction conditions with high atom efficiency.

Ligand- and base-free Pd(II)-catalyzed controlled switching between oxidative heck and conjugate addition reactions

A simple change of solvent allows controlled and efficient switching between oxidative Heck and conjugate addition reactions on cyclic Michael acceptor substrates, catalyzed by a cationic Pd(II) catalyst system. Both reactions are ligand- and base-free and tolerant of air and moisture, and the controlled switching sheds light on some of the factors which favor one reaction over the other.