116673-95-1Relevant articles and documents
An efficient synthesis of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3- dihydro-lh-pyrrolizine, a key intermediate in the licofelone synthesis
Radl, Stanislav,Stach, Jan,Cerny, Josef,Klecan, Ondrej
, p. 1011 - 1022 (2009)
An efficient synthesis of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3- dihydro-1H-pyrrolizine, a key intermediate for the synthesis of licofelone, an anti-inflammatory drug currently undergoing evaluation of the phase-III clinical studies, is described. The method is based on a novel synthesis of unstable 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole, which is then treated with 2-bromo-1-(4-chlorophenyl)ethan-1-one. 2,2-Dimethyl-5-phenylpent-4-ynal with benzylamines provides the corresponding Schiff bases. Migration of the C=N double bond in these N-(2,2-dimethyl-5-phenylpent-4-yn-1-ylidene)benzylamines into conjugation with the aromatic ring using various base/solvent systems was studied. Acid hydrolysis of the formed Schiff bases then provided 2,2-dimethyl-5-phenylpent-4-yn-1-amine and 2,2-dimethyl-5-phenylpenta-3,4-dien- 1-amine; their ratio was influenced mainly by the reaction conditions. Cyclization of these amines using Ag or Au catalysts then led to 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole.
Selective Incorporation of Primary Amines into a Trizirconium Imido System and Catalyic Cyclization of Aminoalkynes
Oishi, Masataka,Nakanishi, Yusuke,Suzuki, Hiroharu
supporting information, p. 9802 - 9813 (2017/08/26)
The trinuclear zirconium imido complex [{LZr(NMe2)}3] (2, L = C5Me4CH2CH2N) was synthesized by amine elimination between Zr(NMe2)4 and endo-olefinic isomers of (tetramethylcyclopentadienyl)ethanamine (LH3) (1). To study the fundamental reactivity of the trizirconium system, reactions of 2 with primary amines were examined. Selective incorporations of the primary amines were observed, depending on steric and electronic natures of the amine substrates. The amine-incorporated complexes [(LZrNHR)(LHZrNHR)(LHZr)(μ-NHR)(μ3-NR)] (3, R = Pr, Et), [(LZrNHR)2(LHZr)(μ-NR)] (4, R = Pr, i-Bu), [(LZr)2(LZrNMe2)(μ-NR)] (5, R = neo-Pen), and [(LZr)(LZrNHAr)(LH2Zr)(μ-NAr)2] (6, Ar = Ph, C6H4-4-Br, C6H4-4-OMe) were structurally characterized by NMR and XRD analysis and showed several coordination modes of the substrate nitrogen ligands: i.e., terminal amides, bridging amides, and bridging imides but not terminal imides. Thermolysis of a mixture of 3 and 4 led to C-H bond activation, giving rise to the zirconaaziridines [{LZr(η2-NCHR)}(LZr)(LHZr)(μ-NHCH2R)] (12, R = Et, Me). Complex 2 proved to be a competent precatalyst in the hydroamination of the aminoalkynes (H2NCH2CR12CH2C=CR2) (13, R1 = H, R2 = Bu, Ph, t-Bu; 14, R1 = Me, R2 = Et, Ph). Stoichiometric or semicatalytic reactions of 2 and the aminoalkynes were studied to explore the reactivity of in situ formed Zr3 species.
Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives
Liu, Wukun,Zhou, Jinpei,Bensdorf, Kerstin,Zhang, Huibin,Liu, Haoran,Wang, Yubin,Qian, Hai,Zhang, Yanchun,Wellner, Anja,Rubner, Gerhard,Huang, Wenlong,Guo, Cancheng,Gust, Ronald
scheme or table, p. 907 - 913 (2011/04/19)
A series of C5-substituted licofelone ([2,2-dimethyl-6-(4-chlorophenyl)-7- phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid) derivatives were developed by a parallel synthesis approach and investigated for cytotoxicity against MCF-7 and MDA-MB-231 cells as well as for anti-inflammatory potency in vitro and in vivo. Dependent on the C5-substituent, the compounds showed high selectivity for MCF-7 cells. Especially 2-oxoethyl benzoate derivatives were inactive at the MDA-MB-231 cell line and as active as 5-FU at MCF-7 cells. C5-acetyl (8a), -2-oxoethyl formiate (8e), -2-oxoethyl acetate (8f) and -2-oxoethyl propionate (8g) derivatives showed growth inhibition at both cell lines, comparable with cisplatin. Modifications significantly reduced the inhibitory potency at COX-1 and COX-2 in vitro and in the xylene-induced ear swelling assay in mice. Only compound 8a was equipotent to licofelone, ibuprofen and celecoxibe in vivo.