1178894-30-8

Basic information

• Product Name: 3-chloro-4-(6-fluoro-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione
• Synonyms: 3-chloro-4-(6-fluoro-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione
• CAS NO: 1178894-30-8
• Molecular Weight: 340.741
• Mol File: 1178894-30-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-chloro-4-(6-fluoro-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4-(6-fluoro-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione(1178894-30-8)
• EPA Substance Registry System: 3-chloro-4-(6-fluoro-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione(1178894-30-8)

Safety Data

• Hazardous Substances Data: 1178894-30-8(Hazardous Substances Data)

Upstream product

• 399-51-9 6-fluoro-1H-indole 
• 3876-05-9 3,4-dichloro-1-phenyl-1H-pyrrole-2,5-dione 

Downstream Products

• 1178894-36-4 3-chloro-4-(6-fluoro-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione 

Relevant articles and documents

Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors

A series of new 3-(indol-3-yl)-4-(pyrazolo[3,4-c]pyridazin-3-yl)-maleimides were synthesized and evaluated for their inhibitory activity against IDH1-R132H. Most compounds exhibited significant potency to IDH1-R132H inhibition. Among these, 3-(1-(3-(1H-imidazol-1-yl)propyl)-6-bromo-1H-indol-3-yl)-4-(1-methyl-1H-pyrazolo[3,4-c]pyridazin-3-yl)-1H-pyrrole-2,5-dione (compound IXb), was the most promising IDH1-R132H inhibitor (IC50 = 0.031 μM) and could significantly inhibit the production of 2-HG in U87MG IDH1-R132H cells. Preliminary structure–activity relationships and molecular modeling studies are discussed based on the experimental data obtained.

Synthesis and biological evaluation of 3-chloro-4-(indol-3-yl)-2,5- pyrroledione derivatives as antitumor agents

A series of 3-chloro-4-(indol-3-yl)-2,5-pyrroledione derivatives were synthesized and evaluated for their cytotoxic activities in vitro against five human cancer cell lines (K562, A549, ECA-109, KB and SMMC-7721). Most compounds displayed potent cytotoxicity with IC50 values in low micromolar range. The results showed that the existence of the chlorine atom at 3-position on the pyrroledione ring was crucial for the activity. Compound 6a, the most potent one (IC50: 0.67～3.93 μM), would be a promising template for further development of novel antitumor agents.