118081-34-8 Usage
Description
Ceftibuten dihydrate is a third-generation cephalosporin antibiotic, characterized as a light-yellow solid. It is the dihydrate form of ceftibuten and is used as an orally administered treatment for urinary-tract and respiratory-tract infections. Its role as an antibacterial drug is attributed to its ability to contain a ceftibuten, which effectively combats several infectious diseases.
Uses
Used in Pharmaceutical Industry:
Ceftibuten dihydrate is used as an antibiotic for treating urinary-tract and respiratory-tract infections. Its application is based on its effectiveness in curing several infectious diseases, making it a valuable component in the development of medications for these purposes.
Used in Preparation of Ceftibuten Crystal:
Ceftibuten dihydrate is also utilized in the preparation of Ceftibuten crystal, which is another form of the antibiotic that can be used for similar therapeutic applications. This process allows for the creation of different pharmaceutical products that can cater to various patient needs and preferences.
Biological Activity
Ceftibuten is an orally bioavailable broad-spectrum cephalosporin antibiotic that inhibits the growth of B. catarrhalis, H. influenzae, pathogenic Neisseria, Streptococcus, penicillin-susceptible S. pneumoniae, and eleven Enterobacteriaceae strains (MICs = 0.25, ≤0.06, ≤0.06, 0.5-1, 4, and ≤0.06-0.5 μg/ml, respectively).1,2 Ceftibuten is also active against E. coli expressing β-lactamase type I, III, and V and K. oxytoca expressing β-lactamase type IV (MICs = 8, 0.25, 0.5, and ≤0.06 μg/ml, respectively) as well as a panel of eight bacterial stains expressing plasmid-encoded extended spectrum β-lactamases, including E. coli CTX-M and K. pneumoniae SHV-2 (MICs = 1 and 0.25 μg/ml, respectively). In vivo, ceftibuten reduces the number of mice killed within 6 days of a K. pneumoniae, E. coli, S. pneumoniae, or S. aureus infection by 50% when administered subcutaneously at doses of 0.125, 2, 1,024, and >512 mg/kg, respectively.3 Formulations containing ceftibuten have been used in the treatment of bacterial infections including bronchitis, pneumonia, and enteritis.
Pharmacokinetics
Ceftibuten Dihydrate is the dihydrate form of ceftibuten, a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Ceftibuten binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Check Digit Verification of cas no
The CAS Registry Mumber 118081-34-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,0,8 and 1 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 118081-34:
(8*1)+(7*1)+(6*8)+(5*0)+(4*8)+(3*1)+(2*3)+(1*4)=108
108 % 10 = 8
So 118081-34-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H14N4O6S2.2H2O/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19;;/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25);2*1H2/b6-1-;;/t10-,13-;;/m1../s1