118132-91-5

Basic information

• Product Name: (1,1-Dimethyl-2-phenyl-ethyl)-phosphoramidic acid diethyl ester
• Synonyms: (1,1-Dimethyl-2-phenyl-ethyl)-phosphoramidic acid diethyl ester
• CAS NO: 118132-91-5
• Molecular Weight: 285.323
• Mol File: 118132-91-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1,1-Dimethyl-2-phenyl-ethyl)-phosphoramidic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1,1-Dimethyl-2-phenyl-ethyl)-phosphoramidic acid diethyl ester(118132-91-5)
• EPA Substance Registry System: (1,1-Dimethyl-2-phenyl-ethyl)-phosphoramidic acid diethyl ester(118132-91-5)

Safety Data

• Hazardous Substances Data: 118132-91-5(Hazardous Substances Data)

Upstream product

• 83386-09-8 2-azido-2-methyl-3-phenylpropane 
• 5774-49-2 2,2-dimethyl-N-(diethoxyphosphoryl)aziridine 
• 118132-85-7 1,1-Dimethyl-2-phenyl-ethyl-phosphorimidic acid triethyl ester 
• 100-86-7 2-Methyl-1-phenyl-2-propanol 
• 32755-15-0 diethyl N-(2-bromo-2-methylpropyl)-phosphoramidate 

Downstream Products

• 122-09-8 Phentermin 

Relevant articles and documents

Synthesis of primary sec-alkylamines via nucleophilic ring-opening of N-phosphorylated aziridines

The novel ring-opening reaction of various 2-alkyl- and 2,2-dimethyl-N-(diethoxyphosphoryl)aziridines (1) and (10) with copper-modified Grignard reagents proceeds regiospecifically at the less hindered carbon. The diethyl N-sec-alkylphosphoramidates (2) thus obtained may efficiently be converted to primary sec-alkylamine hydrochlorides (3) by refluxing with 20% hydrochloric acid. 2,3-Disubstituted N-phosphorylated aziridines except N-phosphorylated cyclohexenimine (4) do not react under the described conditions. Copper-mediated reaction of 2-phenyl-N-(diethoxyphosphoryl)aziridine (7) with Grignard reagents affords a mixture of regioisomers (8) and (9) but still with the preference of ring-opening at the carbon of lesser substitution.