1181399-48-3

Basic information

• Product Name: (S)-phenethyl 2-(6-methoxynaphthalen-2-yl)propanoate
• Synonyms: (S)-phenethyl 2-(6-methoxynaphthalen-2-yl)propanoate
• CAS NO: 1181399-48-3
• Molecular Weight: 334.415
• Mol File: 1181399-48-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-phenethyl 2-(6-methoxynaphthalen-2-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-phenethyl 2-(6-methoxynaphthalen-2-yl)propanoate(1181399-48-3)
• EPA Substance Registry System: (S)-phenethyl 2-(6-methoxynaphthalen-2-yl)propanoate(1181399-48-3)

Safety Data

• Hazardous Substances Data: 1181399-48-3(Hazardous Substances Data)

Upstream product

• 60-12-8 2-phenylethanol 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 
• 1181398-71-9 phenethyl 2-(6-methoxynaphthalen-2-yl)acetate 
• 74-88-4 methyl iodide 

Downstream Products

• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 

Relevant articles and documents

Phase-transfer catalyzed asymmetric arylacetate alkylation

Phenethyl arylacetates are alkylated under phase-transfer conditions with cinchona catalysts with alkyl halides in high yield with excellent enantioselectivity (84-99% ee) following recrystallization. Cinchonidine (CD) derived catalyst gave the (R)-product and cinchonine (CN) catalyst produced the (S)-product. The phenethyl (PE) ester group is removed, using ammonium formate and catalytic Pd/C, to give alkylated carboxylic acid products in high selectivity. The utility of the approach is demonstrated by a direct synthesis of (S)-naproxen.