118149-31-8

Basic information

• Product Name: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate
• Synonyms: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate
• CAS NO: 118149-31-8
• Molecular Weight: 906.904
• Mol File: 118149-31-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate(118149-31-8)
• EPA Substance Registry System: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate(118149-31-8)

Safety Data

• Hazardous Substances Data: 118149-31-8(Hazardous Substances Data)

Upstream product

• 118149-24-9 O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) hydrogenphosphonothioate 
• 5204-74-0 triethylammonium acetate 
• 21090-30-2 3'-O-acetylthymidine 
• 650599-82-9 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(N,N-diisopropylamino)[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]phosphinyl]thymidine 
• 104655-84-7 5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite 
• 118149-23-8 O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) N,N-diisopropylphosphoramidite 
• 127088-91-9 triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 189153-41-1 C₄₉H₅₂N₅O₁₄PS 
• 1196870-93-5 5'-O-dimethoxytritylthymidine-3'-O-(2-oxo-1,3,2-dithiaphospholane) 
• 189153-27-3 Thiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-chloro-2-nitro-benzyl) ester O'-(2-cyano-ethyl) ester 
• 102987-83-7 5′-O-(4,4′-dimethoxytrityl)thymidine-3′-O-[2-cyanoethyl]phosphonate 
• 98796-51-1 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 
• 50-89-5 thymidine 

Downstream Products

• 92127-24-7 C₄₁H₄₅N₄O₁₃PS 

Relevant articles and documents

Chemoselective synthesis of dithymidine phosphorothioate in solution using O-protected thiophosphate monomers

Diastereomerically pure O-protected thymine monothioate nucleotide (I) is efficiently coupled to protected thymidine (II) in a chemoselective, but not stereoselective manner, to give dithymidine phosphorothioates (III).

O-Methyl-bis-O-(4-nitrophenyl)phosphite: a novel chemoselective O-phosphitylating reagent

A novel chemoselective O-phosphitylating reagent containing two aryloxy leaving groups at a P(III) center is developed for selective formation of P(III) esters from amino alcohols without the need to protect the amino group. The reagent proved to be highl

Solution phase synthesis of dithymidine phosphorothioate by a phosphotriester method using new S-protecting groups

A phosphotriester method for the synthesis of dithymidine phosphorothioates with eight S-protecting groups has been investigated. Three of the S-protecting groups possesed catalytic activity, however side reactions occurred under deprotection. The best S-protecting group was 4- chloro-2-nitrobenzyl which could be removed with a minimum of side reactions (0.3 %). The coupling reagent PyFNOP (11) gave protected dithymidine phosphorothioate in 96 % yield after 15 min coupling.