118289-55-7 Usage
Description
5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one, also known as 6-Chloro-5-(2-chloroethyl)oxindole (CAS# 118289-55-7), is an organic compound with significant utility in various fields of chemical and pharmaceutical research. It is characterized by its pale pink solid appearance and is recognized for its unique chemical properties that make it a valuable component in organic synthesis.
Uses
Used in Organic Synthesis:
5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with diverse applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one is used as a building block for the development of new drugs. Its chemical properties make it a promising candidate for the creation of novel therapeutic agents, particularly in the areas of cancer treatment and other medical conditions.
Used in Chemical Research:
5-Chloroethyl-6-chloro-1,3-dihydro-2H-indole-2-one is also utilized in chemical research to study the properties and behavior of similar compounds. This helps scientists understand the underlying mechanisms and interactions of these molecules, which can lead to the discovery of new applications and uses.
Check Digit Verification of cas no
The CAS Registry Mumber 118289-55-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,2,8 and 9 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 118289-55:
(8*1)+(7*1)+(6*8)+(5*2)+(4*8)+(3*9)+(2*5)+(1*5)=147
147 % 10 = 7
So 118289-55-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H9Cl2NO/c11-2-1-6-3-7-4-10(14)13-9(7)5-8(6)12/h3,5H,1-2,4H2,(H,13,14)
118289-55-7Relevant articles and documents
Improved process for the preparation of 6-chloro-5-(2-chloroethyl)oxindole
Nadkarni, Durgesh V.,Hallissey, James F.
, p. 1142 - 1145 (2008)
The current process for ziprasidone involves preparation and isolation of the key intermediate 6-chloro-5-(2-chloroethyl)oxindole. An improved process for the synthesis of this intermediate is reported here. The new process involves use of a novel Lewis acid-mediated selective deoxygenation of the precursor ketone with tetramethyldisiloxane. The new method affords the desired compound in a one-pot process obviating the need for isolation of the potentially hazardous precursor ketone. This process was successfully scaled up to multikilo scale.
Process for the preparation of ziprasidone
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Page/Page column 3, (2008/06/13)
A process for the preparation of ziprasidone and a novel intermediate useful in its preparation. The process comprises the reduction of a compound (III) to give a compound (V) which is then reduced to compound (II). This is reacted with compound (IV) to give the desired compound.
Ziprasidone process
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Page/Page column 7, (2008/06/13)
A process for preparing ziprasidone having low levels of keto ziprasidone and hydroxy ziprasidone impurities.