1185737-50-1 Usage
Description
(4S,5R)-5-(3,5-bis-trifluoromethyl-phenyl)-3-(2-bromo-5-trifluoromethyl-benzyl)-4-methyl-oxazolidin-2-one is a complex organic molecule characterized by its specific stereochemistry and the presence of a five-membered oxazolidinone ring. It features various substituent groups, including trifluoromethyl, bromo, phenyl, and methyl groups. (4S,5R)-5-(3,5-bis-trifluoromethyl-phenyl)-3-(2-bromo-5-trifluoromethyl-benzyl)-4-methyl-oxazolidin-2-one's structure is defined by its chiral centers and three-dimensional shape, which may influence its potential pharmacological or chemical properties. Further research into this compound could reveal its applications in fields such as pharmaceuticals, materials science, or chemical synthesis.
Uses
Used in Pharmaceutical Applications:
(4S,5R)-5-(3,5-bis-trifluoromethyl-phenyl)-3-(2-bromo-5-trifluoromethyl-benzyl)-4-methyl-oxazolidin-2-one is used as a potential pharmaceutical compound for its unique structural features. The presence of trifluoromethyl and bromo groups, along with the chiral centers, may contribute to its interaction with biological targets, making it a candidate for the development of new drugs.
Used in Materials Science:
In the field of materials science, (4S,5R)-5-(3,5-bis-trifluoromethyl-phenyl)-3-(2-bromo-5-trifluoromethyl-benzyl)-4-methyl-oxazolidin-2-one could be utilized for the development of novel materials with specific properties. Its structural characteristics may allow for tailored material properties, such as enhanced stability or unique mechanical properties.
Used in Chemical Synthesis:
(4S,5R)-5-(3,5-bis-trifluoromethyl-phenyl)-3-(2-bromo-5-trifluoromethyl-benzyl)-4-methyl-oxazolidin-2-one may also find use in chemical synthesis as a building block or intermediate for the creation of more complex molecules. Its unique functional groups and stereochemistry could be exploited in the synthesis of advanced chemical compounds with specific applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1185737-50-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,5,7,3 and 7 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1185737-50:
(9*1)+(8*1)+(7*8)+(6*5)+(5*7)+(4*3)+(3*7)+(2*5)+(1*0)=181
181 % 10 = 1
So 1185737-50-1 is a valid CAS Registry Number.
1185737-50-1Relevant articles and documents
SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors
Lu, Zhijian,Chen, Yi-Heng,Napolitano, Joann B.,Taylor, Gayle,Ali, Amjad,Hammond, Milton L.,Deng, Qiaolin,Tan, Eugene,Tong, Xinchun,Xu, Suoyu S.,Latham, Melanie J.,Peterson, Laurence B.,Anderson, Matt S.,Eveland, Suzanne S.,Guo, Qiu,Hyland, Sheryl A.,Milot, Denise P.,Chen, Ying,Sparrow, Carl P.,Wright, Samuel D.,Sinclair, Peter J.
scheme or table, p. 199 - 203 (2012/02/16)
SAR studies of the substitution effect on the central phenyl ring of the biphenyl scaffold were carried out using anacetrapib (9a) as the benchmark. The results revealed that the new analogs with substitutions to replace trifluoromethyl (9a) had a significant impact on CETP inhibition in vitro. In fact, analogs with some small groups were as potent or more potent than the CF3 derivative for CETP inhibition. Five of these new analogs raised HDL-C significantly (>20 mg/dL). None of them however was better than anacetrapib in vivo. The synthesis and biological evaluation of these CETP inhibitors are described.
