1187932-69-9 Usage
Description
3(R)-Iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and bioactive molecules. It is characterized by its unique chemical structure, which includes an iodomethyl group and a tert-butyl ester group, making it a versatile building block in the development of novel therapeutic agents.
Uses
Used in Pharmaceutical Industry:
3(R)-Iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is used as a reactant in the preparation of non-peptidic αvβ6 integrin antagonists. These antagonists are important in the development of therapeutics for various diseases, including cancer and fibrosis, as they can modulate cell adhesion and migration processes.
In the synthesis of non-peptidic αvβ6 integrin antagonists, 3(R)-Iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester plays a crucial role due to its unique chemical properties. Its iodomethyl group can be further functionalized or used in subsequent reactions to form the desired bioactive molecules, while the tert-butyl ester group can be selectively removed under mild conditions, allowing for the introduction of other functional groups or moieties.
Overall, 3(R)-Iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is a valuable compound in the pharmaceutical industry, particularly in the development of novel therapeutic agents targeting αvβ6 integrin. Its unique chemical structure and reactivity make it an essential building block in the synthesis of bioactive molecules with potential applications in the treatment of various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1187932-69-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,9,3 and 2 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1187932-69:
(9*1)+(8*1)+(7*8)+(6*7)+(5*9)+(4*3)+(3*2)+(2*6)+(1*9)=199
199 % 10 = 9
So 1187932-69-9 is a valid CAS Registry Number.
1187932-69-9Relevant articles and documents
INTEGRIN INHIBITORS
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Paragraph 0093-0094, (2020/03/17)
Disclosed are small molecule inhibitors of αvβ6 integrin, and methods of using them to treat a number of diseases and conditions.
NAPHTHYRIDINE DERIVATIVES AS ALPHA V BETA 6 INTEGRIN ANTAGONISTS FOR THE TREATMENT OF E.G. FIBROTIC DISEASES
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Page/Page column 32; 33, (2016/04/20)
A compound of formula (I) or a salt thereof wherein R1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono- or di-substituted pyrazole, an N- or a C-linked optionally mono- or di-substituted triazole or an N- or a C-linked optionally mono-or di-substituted imidazole, which five-membered aromatic heterocycle may be substituted by one or two of the groups selected from a hydrogen atom, a methyl group, an ethyl group, a fluorine atom, a hydroxymethyl group, a 2-hydroxypropan-2-yl group, a trifluoromethyl group, a difluoromethyl group or a fluoromethyl group, except that when R1 represents an N-linked mono-or di-substituted pyrazole, R1 does not represent 3,5-Dimethyl-1H- pyrazol-1-yl, 5-Methyl-1H-pyrazol-1-yl, 5-Ethyl-3-methyl-1H-pyrazol-1-yl, 3,5-Diethyl-1H-pyrazol-1- yl, 4-Fluoro-3,5-dimethyl-1H-pyrazol-1-yl, 3-Methyl-1H- pyrazol-1-yl or 1H- pyrazol-1-yl.
TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
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Paragraph 00241-00243, (2014/05/24)
The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
