1188330-70-2

Basic information

• Product Name: (R)-3-(4-bromo-3-fluoro-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one
• Synonyms: (R)-3-(4-bromo-3-fluoro-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one
• CAS NO: 1188330-70-2
• Molecular Weight: 404.351
• Mol File: 1188330-70-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-(4-bromo-3-fluoro-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(4-bromo-3-fluoro-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one(1188330-70-2)
• EPA Substance Registry System: (R)-3-(4-bromo-3-fluoro-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one(1188330-70-2)

Safety Data

• Hazardous Substances Data: 1188330-70-2(Hazardous Substances Data)

Upstream product

• 149524-42-5 (5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 444335-16-4 (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one 

Downstream Products

• 627541-90-6 (R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-[3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-oxazolidin-2-one 
• 1188918-65-1 (R)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one 
• 1188337-58-7 2-{4-[5-((R)-tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-acrylic acid ethyl ester 
• 1188918-58-2 (R)-3-[2-fluoro-4'-(2-methyl-6-nitro-2,3-dihydro-imidazo[2,1-b]oxazol-2-yl)-biphenyl-4-yl]-5-hydroxymethyl-oxazolidin-2-one 
• 1188337-61-2 (R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-[3-fluoro-4-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-phenyl]-oxazolidin-2-one 
• 1188337-60-1 (R)-3-{4-[2-(2-bromo-4-nitro-imidazol-1-yl)1-hydroxymethyl-ethyl]-3-fluoro-phenyl}-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one 
• 1188918-43-5 (R)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-5-hydroxymethyl-oxazolidin-2-one 
• 1188337-59-8 3-(2-bromo-4-nitro-imidazol-1-yl)-2-{4-[(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-propionic acid ethyl ester 
• 1188335-29-6 (R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one 
• 1835340-19-6 (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate 
• 856866-72-3 (5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one 

Relevant articles and documents

Nickel catalyzed tedizolid phosphate synthesis method

The invention discloses a nickel catalyzed tedizolid phosphate synthesis method. The method includes that methyl tetrazolium bromopyridine serving as an electrophilic reagent and N-oxazolidinone phenyl zinc halide serving as a nucleophilic reagent are subjected to nickel catalyzed Negishi coupling reaction and in-situ deprotection to obtain pharmaceutically active molecular tedizolid through a two-step one-pot process, and tedizolid is subjected to phosphoric acid esterification to obtain tedizolid phosphate. The method has advantages that 1) by in-situ synthesis and utilization of the organiczinc reagent, a complex step of metal reagent separation is avoided; 2) a cheap nickel catalyzing system is applied to establishment of a tedizolid phosphate core framework for the first time, and efficiency of nickel catalyzed Negishi coupling reaction is equivalent to that of palladium catalyzed Suzuki coupling reaction in current industrial synthesis of tedizolid phosphate. The remarkable advantages are beneficial to improvement of efficiency in tedizolid phosphate synthesis and production cost reduction, and the nickel catalyzed tedizolid phosphate synthesis method has a promising industrial application prospect.