119-81-3 Usage
Description
4-METHOXY-2-NITROACETANILIDE is a chemical compound that serves as a derivative of Methacetin (M258770). It is characterized by the presence of a nitro group and a methoxy group attached to an acetanilide structure. 4-METHOXY-2-NITROACETANILIDE is utilized in various chemical reactions and synthesis processes, particularly in the production of pharmaceuticals and other organic compounds.
Uses
Used in Pharmaceutical Synthesis:
4-METHOXY-2-NITROACETANILIDE is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable component in the development of new drugs and therapeutic agents.
Used in the Synthesis of Thiabendazole:
One of the primary applications of 4-METHOXY-2-NITROACETANILIDE is in the synthesis of Thiabendazole (T344150), an active pharmaceutical ingredient. Thiabendazole is a widely used antifungal agent, effective against a variety of fungal infections. The synthesis of this compound involves the use of 4-METHOXY-2-NITROACETANILIDE as a key intermediate, highlighting its importance in the production of this essential medication.
Used in Chemical Research:
4-METHOXY-2-NITROACETANILIDE is also employed in chemical research, where it can be used to study the properties and reactions of various organic compounds. Its unique structure and reactivity make it an interesting subject for research, potentially leading to the discovery of new compounds and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 119-81-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 119-81:
(5*1)+(4*1)+(3*9)+(2*8)+(1*1)=53
53 % 10 = 3
So 119-81-3 is a valid CAS Registry Number.
119-81-3Relevant articles and documents
Fused tricyclic derivative as FGFR4 inhibitor
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Paragraph 0597-0602, (2021/05/12)
The present invention provides a fused tricyclic derivative that is the selective inhibitor of fibroblast growth factor receptor 4 (FGFR4), a pharmaceutical composition containing the compound, a method of making the compound and a method of treating cell proliferative diseases, such as cancer, using the compounds of the invention.
Transition-metal-free mono- or dinitration of protected anilines
Dai, Enrui,Dong, Ying,Dong, Yongrui,Kong, Rui,Liang, Deqiang,Liu, Guangzhang,Ma, Yinhai,Wu, Qiong
, (2020/04/27)
An amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO2 and NaNO3 as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and ortho–para selectivity.
Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation
Wan, Yameng,Zhang, Zhiguo,Ma, Nana,Bi, Jingjing,Zhang, Guisheng
, p. 780 - 791 (2019/01/24)
Novel acylamino-directed relay disubstitutions realize the sequential difunctionalizations of anilides (1) under mild and metal-free conditions for the first time. This [bis(trifluoroacetoxy)iodo]benzene (PIFA) and BF3·Et2O promoted straightforward reaction produces a series of p-acetoxyl- or p-alkoxyl-o-nitro-N-arylamides (2), which are key scaffolds of various drugs, functional materials, and bioactive molecules. The flexibility with respect to the functional groups in these products affords this novel protocol excellent versatility for synthetic applications.