1194-78-1Relevant articles and documents
2-amino-6-chloropurine as well as synthesis method, intermediate and application thereof
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Paragraph 0066; 0067; 0069; 0070; 0072; 0073, (2020/01/12)
The invention belongs to the technical field of medicines and in particular relates to 2-amino-6-chloropurine as well as a synthesis method, an intermediate and application thereof. The synthesis method of the 2-amino-6-chloropurine comprises the following steps: performing a primary reaction, namely mixing ethyl cyanoacetate, chloroformamidine hydrochloride, liquid ammonia and sodium to implementa reaction so as to generate an intermediate; performing a secondary reaction, namely mixing the intermediate with formic acid to implement a reaction; adding a sodium hydroxide solution into the product of the secondary reaction till alkali; and performing filtering and drying, so as to obtain 2-amino-6-chloropurine. Raw materials are low in price and easy to obtain, reaction steps are small, the reaction time is short, a large amount of wastewater is not generated, and industrial production can be facilitated.
COMPOUNDS FOR IMPROVING MRNA SPLICING
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Page/Page column 225, (2016/08/10)
Provided herein are compounds useful for improving mRNA splicing in a cell. Exemplary compounds provided herein are useful for improving mRNA splicing in genes comprising at least one exon ending in the nucleotide sequence CAA. Methods for preparing the compounds and methods of treating diseases of the central nervous system are also provided.
Bis (hydroxymethyl) cyclobutyl triazolopyrimidines
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, (2008/06/13)
Antiviral activity is exhibited by compounds having the formula STR1 and its pharmaceutically acceptable salts wherein R1 is STR2 R6 is hydrogen, alkyl, substituted alkyl, or aryl; and R7 and R8 are independentl