119520-56-8

Basic information

• Product Name: Pyridine, 2-(cyclohexylthio)-
• CAS NO: 119520-56-8
• Molecular Formula: C11H15NS
• Molecular Weight: 193.313
• Mol File: 119520-56-8.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-(cyclohexylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(cyclohexylthio)-(119520-56-8)
• EPA Substance Registry System: Pyridine, 2-(cyclohexylthio)-(119520-56-8)

Safety Data

• Hazardous Substances Data: 119520-56-8(Hazardous Substances Data)

Upstream product

• 79-35-6 1,1'-dichloro-2,2'-difluoroethene 
• 105398-69-4 Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 79-06-1 2-propenamide 
• 5535-48-8 PVS 
• 32999-09-0 2-cyclohexylbenzo-[d][1,3,2]dioxaborole 
• 266339-14-4 N-methoxycarbonyloxy-pyridine-2-thione 
• 292638-85-8 acrylic acid methyl ester 
• 1121-30-8 1-hydroxy-2(1H)-pyridinethione 
• 110-82-7 cyclohexane 
• 109-04-6 2-bromo-pyridine 
• 1569-69-3 Cyclohexanethiol 
• 18438-38-5 2-methylsulfanyl-pyridine 
• 109-09-1 2-chloropyridine 
• 108-85-0 1-bromocyclohexane 

Downstream Products

• 135763-96-1 cyclohexyl 2-pyridyl sulfoxide 

Relevant articles and documents

The functionalization of saturated hydrocarbons. Part 34. A study on the mechanism of tempo trapping in GIF-type systems

The photolysis of Barton PTOC esters (radical reaction) in presence of Tempo produces alkyl-Tempo in very good yield. Good results are also obtained with Fe(II)-H2O2 system (pyridine, Picolinic Acid, hydrocarbon). In this case the Fe(II)-Fe(IV) manifold is responsible for the formation of the adduct. Using Fe(III)-H2O2, Tempo adduct is formed at the same rate as the oxidation products. Mechanistic studies suggest the oxidation of Tempo by the Fe(V) to give an oxoammonium salt and an Fe(IV) species.

Synthesis method of heteroaryl thioether

The invention discloses a synthesis method of heteroaryl thioether. Under the conditions of no catalyst, no solvent, no additive and the like, aryl halide/2-bromopyridine, thiourea and substituted benzyl bromide which are directly taken as raw materials to selectively synthesize asymmetric heteroaryl thioether in one step without using conventional organic sulfides such as mercaptan or thiophenol.The use of organic sulfides with high toxicity and heavy odor, such as mercaptan or thiophenol, is avoided, and the synthesis steps are shortened, so that the synthesis efficiency is improved, the reaction has good selectivity, and the asymmetric thioether can be preferentially obtained.

Nickel-Catalyzed Inter- and Intramolecular Aryl Thioether Metathesis by Reversible Arylation

A nickel-catalyzed aryl thioether metathesis has been developed to access high-value thioethers. 1,2-Bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional-group-tolerant reaction. Furthermore, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring-closing metathesis that does not involve alkene bonds. In-depth organometallic studies support a reversible Ni0/NiII pathway to product formation. Overall, this work not only provides a more sustainable alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information that are highly relevant to the further development and application of unusual single-bond metathesis reactions.