1201837-04-8

Basic information

• Product Name: (S)-2-(4-chloro-benzoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (S)-2-(4-chloro-benzoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1201837-04-8
• Molecular Weight: 309.793
• Mol File: 1201837-04-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-2-(4-chloro-benzoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(4-chloro-benzoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester(1201837-04-8)
• EPA Substance Registry System: (S)-2-(4-chloro-benzoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester(1201837-04-8)

Safety Data

• Hazardous Substances Data: 1201837-04-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 147-85-3 L-proline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 115186-37-3 tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 1201837-05-9 (4-chloro-phenyl)-(S)-pyrrolidin-2-yl-methanone hydrochloride 
• 1201836-82-9 {(S)-2-[(4-chlorophenyl)-fluoro-methyl]-pyrrolidin-1-yl}-(3-difluoromethyl-1-methyl-1H-pyrazol-4-yl)-methanone 
• 1201836-81-8 {(S)-2-[(4-chlorophenyl)-hydroxy-methyl]-pyrrolidin-1-yl}-(3-difluoromethyl-1-methyl-1H-pyrazol-4-yl)-methanone 

Relevant articles and documents

Formal Fluorinative Ring Opening of 2-Benzoylpyrrolidines Utilizing [1,2]-Phospha-Brook Rearrangement for Synthesis of 2-Aryl-3-fluoropiperidines

A ring expansion of 2-benzoylpyrrolidines, which involves the formal fluorinative ring opening utilizing the [1,2]-phospha-Brook rearrangement under Br?nsted base catalysis and a subsequent intramolecular reductive amination, was developed. The operationally simple three-step protocol provides an efficient access to 2-aryl-3-fluoropiperidines. The methodology was further applied to the syntheses of azepanes and tetrahydroquinolines.

Novel Microbiocides

Compounds of Formula (I), in which the substituents are as defined in claim 1, are suitable for use as microbiocides.