1204295-99-7

Basic information

• Product Name: 2-(2,2,2-trifluoroethyl)naphthalene
• Synonyms: 2-(2,2,2-trifluoroethyl)naphthalene
• CAS NO: 1204295-99-7
• Molecular Weight: 210.199
• Mol File: 1204295-99-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2,2,2-trifluoroethyl)naphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,2,2-trifluoroethyl)naphthalene(1204295-99-7)
• EPA Substance Registry System: 2-(2,2,2-trifluoroethyl)naphthalene(1204295-99-7)

Safety Data

• Hazardous Substances Data: 1204295-99-7(Hazardous Substances Data)

Upstream product

• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 1592-38-7 2-Naphthalenemethanol 

Relevant articles and documents

Dehydroxylative Trifluoromethylthiolation, Trifluoromethylation, and Difluoromethylation of Alcohols

CF3S, CF3 and HCF2 groups have been identified as valuable functionalities for drug development. Despite significant accomplishments in the trifluoromethylthiolation, trifluoromethylation and difluoromethylation reactions, directly converting common functional groups into CF3S, CF3 or HCF2 groups is still highly desirable. Described here is the dehydroxylative trifluoromethylthiolation, trifluoromethylation and difluoromethylation of alcohols promoted by a R3P/ICH2CH2I system. All of these dehydroxylative reactions were achieved under mild conditions via the activation of the hydroxyl group by the R3P/ICH2CH2I system. A wide substrate scope and good functional group tolerance were observed.