12107-56-1Relevant articles and documents
Green, Michael,Laguna, Antonio,Spencer, John L.,Stone, F. Gordon A.
, (1977)
Dual application of Pd nanoparticles supported on mesoporous silica SBA-15 and MSU-2: Supported catalysts for C-C coupling reactions and cytotoxic agents against human cancer cell lines
Balbn, Adriana,Gaballo, Francesco,Ceballos-Torres, Jess,Prashar, Sanjiv,Fajardo, Mariano,Kaluderovi, Goran N.,Gmez-Ruiz, Santiago
, p. 54775 - 54787 (2014)
Two different mesoporous silica-based materials (SBA-15 and MSU-2) have been treated under mild conditions with different quantities of [PdCl2(cod)] (cod = 1,5-cyclooctadiene) to promote the formation of supported palladium nanoparticles (materials of the type SBA-15-Pd and MSU-2-Pd). The synthesized materials have been characterized by different techniques observing that the palladium nanoparticles remain impregnated in the silica. The catalytic activity of the hybrid Pd-silica materials has been tested in Suzuki-Miyaura C-C coupling reactions observing moderate conversion rates in the reactions of 3-bromoanisole with 4-carboxyphenylboronic acid and 2-bromopyridine with 4-carboxyphenylboronic acid. In addition, the synthesized materials showed a good degree of recyclability, being catalytically active in five consecutive catalytic tests. Finally, in order to evaluate the cytotoxicity of the synthesized materials, in vitro tests against five different human cancer cell lines have been carried out, observing high cytotoxic activities of the hybrid systems comparable if not somewhat higher to other systems based on metal complexes supported on mesoporous silicas described previously in the literature. To the best of our knowledge the cytotoxic study reported here represents the first evaluation of the anticancer action of supported palladium nanoparticles in human cancer cells.
Rettig,M.F.,Wing,R.M.,Wiger,G.R.
, p. 2980 (1981)
Method for in-situ preparation of (1, 5-cyclooctadiene) palladium dichloride
-
Paragraph 0043-0062, (2022/03/27)
The invention relates to a method for in-situ preparation of (1, 5-cyclooctadiene) palladium dichloride, and belongs to the technical field of preparation of noble metal homogeneous catalysts. According to the (1, 5-cyclooctadiene) palladium dichloride prepared by the in-situ method disclosed by the invention, the raw material is palladium powder, and the cost of the raw material is relatively low. Solvents and medicines used in the preparation process are conventional acid-base and alcohol solvents, so that the toxicity is low, the price is low, and the method is suitable for industrial large-scale production. Meanwhile, by adding the complexing accelerant, the use amount of the ligand 1, 5-cyclooctadiene can be effectively reduced, the cost is reduced, and meanwhile, the green and environment-friendly requirements are better met. In addition, high-temperature heating is not needed in the preparation process, reaction conditions are easy to achieve, steps are simple and convenient, the product yield is high, washing is easy, and multiple synthesis steps are directly prepared through a one-pot series connection method. And the product has the characteristics of low metal impurity content and the like, meets the use requirements of the homogeneous catalyst, and is suitable for being used as the homogeneous catalyst in the organic synthesis reaction of various medicines and fine chemical products.
CNN Coordination Accelerates the iClick Reaction of Square-Planar Palladium(II) and Platinum(II) Azido Complexes with Electron-Poor Alkynes and Enables Cycloaddition with Terminal Alkynes
Moreth, Dominik,Peng, Kun,Schatzschneider, Ulrich
supporting information, p. 2584 - 2593 (2021/08/20)
Organometal azido complexes with a cyclometalating C^N^N coligand of the general formula [M(N3)(phbpy)] with M = Pd(II) or Pt(II) and Hphbpy = 6-phenyl-2,2′-bipyridine were prepared in very good yield and reacted in a catalyst-free iClick reaction with internal alkynes 4,4,4-trifluoro-2-butynoic acid ethyl ester and dimethyl acetylenedicarboxylate and also methyl propiolate as a prototypical terminal alkyne. At room temperature, the two internal alkynes reacted too fast to study the kinetics with NMR spectroscopy, as the first spectrum obtained after mixing of the reactants showed only the product. Only in the case of methyl propiolate, second-order rate constants were obtained as 7.7 × 10-3 and 5.6 × 10-3 M-1 s-1 for the Pd(II) and Pt(II) azido complexes, respectively. As an alternative method with a shorter lag time, solution IR spectroscopy monitoring the disappearance of the azido vibration was used to obtain pseudo-first-order rate constants in the range of 3-4 × 10-4 s-1 for the terminal alkyne and 10-2 s-1 for the internal alkynes, with a general trend in the reactivity of Pd > Pt and CF3,COOEt > COOCH3,COOCH3 ? H,COOCH3.