121641-60-9Relevant articles and documents
Visible-Light-Induced Dehydrogenative Imidoylation of Imidazo[1,2- a]pyridines with α-Amino Acid Derivatives and α-Amino Ketones
Zhu, Zhi-Qiang,Guo, Dong,Ji, Jiu-Jian,Zhu, Xiao,Tang, Juan,Xie, Zong-Bo,Le, Zhang-Gao
, p. 15062 - 15071 (2020)
A new and efficient visible-light-promoted dehydrogenative cross-coupling reaction of imidazo[1,2-a]pyridines with α-amino carbonyl compounds toward imidoyl imidazo[1,2-a]pyridines is developed. A diverse range of imidazo[1,2-a]pyridines undergoes the dehydrogenative imidoylation smoothly with α-amino carbonyl compounds to access the corresponding products in satisfactory yields. We have also proposed the possible reaction mechanism based on preliminary mechanistic studies. The synthetic method has the advantages of wide substrate scope, good functional tolerance, and mild reaction conditions, which make this transformation more practical and sustainable.
Copper-Catalyzed Aerobic Oxidative Dehydrogenative Formal [2 + 3] Cyclization of Glycine Esters with α-Angelicalactone: Approach To Construct Polysubstituted Pyrrolidones
Huo, Congde,Yuan, Yong,Chen, Fengjuan,Tang, Jing,Wang, Yajun
, p. 4208 - 4211 (2015)
A novel and efficient copper-catalyzed aerobic oxidative dehydrogenative formal [2 + 3] cyclization of glycine derivatives with α-angelicalactone is described. A series of complex pyrrolidones were produced under mild and simple reaction conditions.
Photoinduced iodine-mediated tandem dehydrogenative Povarov cyclisation/C-H oxygenation reactions
Brasholz, Malte,Schendera, Eva,Villinger, Alexander
, p. 6912 - 6915 (2020)
We report metal-free, photoinduced aerobic tandem dehydrogenative Povarov cyclisation/Csp3-H oxygenation reactions between N-aryl glycine esters and α-substituted styrenes, which efficiently lead to 4,4-disubstituted dihydroquinoline-3-ones under mild conditions. The reactions are mediated by iodine along with visible light irradiation, which allows for the in situ generation of the essential Br?nsted acid HI, to catalyse the key imine [4+2]-cycloaddition.
Br?nsted Acid-Catalyzed Three-Component Reaction of Anilines, α-Oxoaldehydes, and α-Angelicalactone for the Synthesis of Complex Pyrrolidones
Huo, Congde,Yuan, Yong
, p. 12704 - 12710 (2015)
A green and efficient three-component reaction of easily available anilines, α-oxoaldehydes, and α-angelicalactone was developed for the synthesis of highly functionalized pyrrolidones using dilute sulfuric acid as the catalyst. Products were obtained in good to high yields at room temperature and under solvent-free conditions. The reaction could also be performed on a multigram scale with the same efficiency.
Visible-Light-Mediated, Chemo- and Stereoselective Radical Process for the Synthesis of C-Glycoamino Acids
Ji, Peng,Zhang, Yueteng,Wei, Yongyi,Huang, He,Hu, Wenbo,Mariano, Patrick A.,Wang, Wei
supporting information, p. 3086 - 3092 (2019/05/01)
An approach for efficient synthesis of C-glycosyl amino acids is described. Different from typical photoredox-catalyzed reactions of imines, the new process follows a pathway in which α-imino esters serve as electrophiles in chemoselective addition reactions with nucleophilic glycosyl radicals. The process is highlighted by the mild nature of the reaction conditions, the highly stereoselectivity attending C-C bond formation, and its applicability to C-glycosylations using both armed and disarmed pentose and hexose derivatives.
