1222-61-3 Usage
Description
(2Z)-3-[4-(dimethylamino)phenyl]-2-phenylprop-2-enenitrile, also known as DMAPN, is a yellow powder with a molecular formula of C18H17N3. It is a compound commonly used as a building block in organic synthesis and pharmaceutical research. DMAPN is known for its potential as a versatile intermediate in the synthesis of various biologically active compounds, including pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Research:
(2Z)-3-[4-(dimethylamino)phenyl]-2-phenylprop-2-enenitrile is used as a building block for the synthesis of various biologically active compounds, particularly in the development of pharmaceuticals. Its versatility as an intermediate allows for the creation of a wide range of potential therapeutic agents.
Used in Medicinal Chemistry:
(2Z)-3-[4-(dimethylamino)phenyl]-2-phenylprop-2-enenitrile is used as a valuable target for research and development in the field of medicinal chemistry. Its potential antiproliferative, anticancer, and anti-inflammatory activities make it a promising candidate for further investigation and application in the development of new drugs.
Used in Agrochemicals:
(2Z)-3-[4-(dimethylamino)phenyl]-2-phenylprop-2-enenitrile is also used as an intermediate in the synthesis of various agrochemicals. Its potential applications in this industry include the development of new pesticides, herbicides, and other agricultural chemicals that can improve crop yields and protect against pests.
Check Digit Verification of cas no
The CAS Registry Mumber 1222-61-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,2 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1222-61:
(6*1)+(5*2)+(4*2)+(3*2)+(2*6)+(1*1)=43
43 % 10 = 3
So 1222-61-3 is a valid CAS Registry Number.
1222-61-3Relevant articles and documents
Pyrenedione-Catalyzed α-Olefination of Nitriles under Visible-Light Photoredox Conditions
Bains, Amreen K.,Ankit, Yadav,Adhikari, Debashis
supporting information, p. 2019 - 2023 (2021/04/05)
Herein, we report a combination of pyrenedione (PD) and KOtBu to achieve facile alcohol dehydrogenation under visible-light excitation, where aerobic oxygen is utilized as the terminal oxidant. The resulting carbonyl compound can be easily converted to vinyl nitriles in a single-pot reaction, at 60 °C in 6-8 h. This environmentally benign, organocatalytic approach has distinct advantages over transition-metal-catalyzed α-olefination of nitriles, which often operate at a significantly higher temperature for an extended reaction time.
α-Cyanostilbene based fluorophores: Aggregation-induced enhanced emission, solvatochromism and the pH effect
Palakollu, Veerabhadraiah,Kanvah, Sriram
, p. 5736 - 5746 (2015/02/19)
A series of α-cyanostilbenes substituted with dimethylaniline, diphenylaniline and carbazole was synthesized and their optical spectroscopic properties in homogeneous solvents, the dioxane-water binary mixture and the solid state were investigated. Stilbe
(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties
Lieber, Sonja,Scheer, Frithjof,Meissner, Wolfgang,Naruhn, Simone,Adhikary, Till,Müller-Brüsselbach, Sabine,Diederich, Wibke E.,Müller, Rolf
supporting information; experimental part, p. 2858 - 2868 (2012/06/15)
The ligand-regulated nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a potential pharmacological target due to its role in disease-related biological processes. We used TR-FRET-based competitive ligand binding and coregulator
