122453-85-4

Basic information

• Product Name: 2-phenyl-1H-pyrrole-4-carbonitrile
• CAS NO: 122453-85-4
• Molecular Weight: 168.198
• Mol File: 122453-85-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-phenyl-1H-pyrrole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1H-pyrrole-4-carbonitrile(122453-85-4)
• EPA Substance Registry System: 2-phenyl-1H-pyrrole-4-carbonitrile(122453-85-4)

Safety Data

• Hazardous Substances Data: 122453-85-4(Hazardous Substances Data)

Usage

General Description

2-phenyl-1H-pyrrole-4-carbonitrile is a chemical compound with the molecular formula C12H8N2. It is a pyrrole derivative with a phenyl group attached to the nitrogen atom. 2-phenyl-1H-pyrrole-4-carbonitrile is commonly used in pharmaceutical research and drug discovery due to its potential biological activities, including anti-inflammatory and anticancer properties. It has also been studied for its role in the synthesis of new organic compounds and materials. 2-phenyl-1H-pyrrole-4-carbonitrile is known for its versatile reactivity and has shown promise in various synthetic and medicinal applications.

Upstream product

• 36635-66-2 α-tosylbenzyl isocyanide 
• 107-13-1 acrylonitrile 
• 31594-51-1 2-phenyl-4-cyano-Δ¹-pyrroline 
• 14476-72-3 2-(2-oxo-2-phenylethyl)malononitrile 

Relevant articles and documents

An Efficient, Scalable and Eco-friendly Synthesis of 4,5-substituted Pyrrole-3-Carbonitriles by Intramolecular Annulation on Pd/C and HZSM-5

An efficient and eco-friendly protocol for the synthesis of diverse 4,5-substituted 1H-pyrrole-3-carbonitriles has been developed using commercially available HZSM-5 and Pd/C as recyclable heterogeneous catalysts with more excellent yields (up to 98 %) than traditional liquids acids, and successfully applied in the practical synthesis of vonoprazan. The conspicuous features of this protocol are higher product yield, easy work-up, eco-friendly and reusability of catalysts.

4-Substituted 2-phenyl- and 2-phenyl-3-aryl pyrroles by reaction of tosyl benzyl isocyanide (TosBIC) with Michael acceptors

Synthesis of 2-phenyl and 2,3-diphenylpyrroles bearing at the 4 position electronwithdrawing groups by reaction of tosylbenzylisocyanide (TosBIC) with various Michael acceptors was investigated. Sodium hydride and n-butyllithium were used as deprotonating agents for the synthesis of monophenyl and diphenylpyrroles, respectively.

Method of controlling phytopathogenic fungi

This invention is directed to a method for the control of phytopathogenic fungi by contacting the same with a cyano- or nitroarylpyrrole compound, or by applying said pyrrole compound to the foliage of a plant susceptible to disease caused by said pathogens.