122536-76-9 Usage
Description
(S)-3-(Boc-amino)pyrrolidine is a chiral, white crystalline powder that serves as a versatile building block in organic synthesis and pharmaceutical chemistry. Its unique structure and properties make it a valuable component in the development of various biologically active compounds.
Uses
Used in Pharmaceutical Industry:
(S)-3-(Boc-amino)pyrrolidine is used as a key intermediate for the synthesis of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives, which are potent inhibitors against EGFR tyrosine kinase. These inhibitors have potential applications in the treatment of various cancers by targeting the epidermal growth factor receptor, a key player in cell proliferation and tumor growth.
Used in Organic Synthesis:
(S)-3-(Boc-amino)pyrrolidine is used as a chiral building block in the asymmetric Morita-Baylis-Hillman reaction. This reaction is a powerful method for the synthesis of chiral functionalized molecules, which are important in the development of pharmaceuticals, agrochemicals, and other bioactive compounds.
Used in Antibacterial Agents:
(S)-3-(Boc-amino)pyrrolidine is used as a precursor for the synthesis of N-benzyl-3-sulfonamidopyrrolidines, which are potent bacterial cell division inhibitors. These compounds have the potential to be developed into new antibiotics to combat drug-resistant bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 122536-76-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,5,3 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 122536-76:
(8*1)+(7*2)+(6*2)+(5*5)+(4*3)+(3*6)+(2*7)+(1*6)=109
109 % 10 = 9
So 122536-76-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H18N2O2/c1-9(2,3)13-8(12)11-7-4-5-10-6-7/h7,10H,4-6H2,1-3H3,(H,11,12)/t7-/m0/s1
122536-76-9Relevant articles and documents
Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold
Gao, Ling-Jie,Schwed, J. Stephan,Weizel, Lilia,De Jonghe, Steven,Stark, Holger,Herdewijn, Piet
, p. 132 - 137 (2013/02/23)
Starting from a known H4R ligand based on a pyrimidine skeleton, a series of novel analogues based on a pyrrolo[2,3-d]pyrimidine scaffold have been prepared. Whereas the original pyrimidine congener shows good affinity at hH4R (Ki = 0.5 μM), its lacks selectivity with a K i value for the hH3R of 1 μM. Within the newly synthesized pyrrolo[2,3-d]pyrimidines, several congeners show Ki values of less than 1 μM at the hH4R and show a much improved selectivity profile. Therefore, these series represent an interesting starting point for the discovery of novel hH4R ligands.
STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES
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Page/Page column 15, (2010/06/22)
This invention relates to dialdehyde or dinitrile compounds, which are useful for stereoselective synthesis of piperidine, pyrrolidine, and azepane derivatives.
Methods of treating insulin resistance syndrome and diabetes
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, (2008/06/13)
This invention is directed to methods of treating insulin resistance syndrome and diabetes in a patient in need thereof, comprising administering to said patient a pharmaceutically effective amount of a compound derived from adenosine and analogues thereof, or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable prodrug thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof, or a pharmaceutical composition comprising such compound.