12279-41-3

Basic information

• Product Name: Seractide
• Synonyms: CORTICOTROPIN (HUMAN);CORTICOTROPHIN;CORTICOTROPIN A;H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE-OH;ACTH (1-39), HUMAN;ACTH 1-39;ACTH;ADRENOCORTICOTROPIC HORMONE HUMAN
• CAS NO: 12279-41-3
• Molecular Formula: C207H308N56O58S1
• Molecular Weight: 4541.07
• EINECS: 232-659-7
• Product Categories: Peptide;Melanocortin receptor
• Mol File: 12279-41-3.mol
• Article Data: 0

Chemical Properties

• Appearance: White lyophilised solid
• Storage Temp.: −20°C
• Solubility: H2O: 1 mg/mL, clear, colorless
• CAS DataBase Reference: Seractide(CAS DataBase Reference)
• NIST Chemistry Reference: Seractide(12279-41-3)
• EPA Substance Registry System: Seractide(12279-41-3)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: GM7900000
• F: 8-10
• Hazardous Substances Data: 12279-41-3(Hazardous Substances Data)

Usage

Description

Seractide is a synthetic polypeptide hormone that functions as an adrenocorticotropic hormone (ACTH) analog. It is a 39-amino acid peptide derived from the native ACTH sequence and is designed to have a longer duration of action and increased potency compared to the natural hormone. Seractide is produced synthetically to ensure consistent quality and purity, and it is used for various therapeutic applications due to its ability to stimulate the adrenal cortex and influence the production of cortisol and other adrenal hormones.
Used in Pharmaceutical Industry:
Seractide is used as a hormone therapy for the treatment of various endocrine disorders and conditions that involve the adrenal cortex. It is particularly useful in cases where the body's natural production of ACTH is insufficient or when the adrenal glands are not responding adequately to the hormone.
Used in Endocrine Therapy:
Seractide is used as an endocrine therapy for the management of primary adrenal insufficiency (Addison's disease), where the adrenal glands do not produce enough cortisol and aldosterone. It helps to replace the missing hormones and maintain normal adrenal function.
Used in Rheumatology:
In the field of rheumatology, Seractide is used as an anti-inflammatory agent for the treatment of various autoimmune and inflammatory conditions, such as rheumatoid arthritis, systemic lupus erythematosus, and vasculitis. Its ability to modulate the immune system and reduce inflammation makes it a valuable treatment option for these conditions.
Used in Dermatology:
Seractide is used in dermatology as a treatment for various skin conditions, including psoriasis, atopic dermatitis, and other inflammatory skin disorders. Its anti-inflammatory and immunomodulatory effects help to reduce skin inflammation, itching, and redness, leading to improved skin health and appearance.
Used in Neurology:
In neurology, Seractide is used as a therapeutic agent for the treatment of multiple sclerosis and other demyelinating diseases of the central nervous system. Its immunosuppressive and anti-inflammatory properties help to reduce the damage to nerve fibers and slow down the progression of the disease.
Used in Oncology:
Seractide is used in oncology as an adjunct therapy for the treatment of certain types of cancer, particularly those that are sensitive to the effects of glucocorticoids. Its ability to modulate the immune system and reduce inflammation can help to improve the efficacy of other cancer treatments and manage cancer-related symptoms.

Biochem/physiol Actions

Adrenocorticotropic hormone (ACTH) stimulates melanocortin receptor (MC1R to MC5R).It is implicated in the production of α-melanocyte-stimulating hormone (α-MSH). Hypomethylation of ACTH promoter region in thymic carcinoids is associated with ectopic adrenocorticotropic hormone syndrome. Mutations in this gene are associated with aberrant fusion protein and impairing melanocortin signaling in hypoadrenalism. Dysregulation of ACTH leads to Cushing disease.