123226-36-8

Basic information

• Product Name: Benzeneacetonitrile, 3-(bromomethyl)-
• CAS NO: 123226-36-8
• Molecular Formula: C9H8BrN
• Molecular Weight: 210.073
• Mol File: 123226-36-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, 3-(bromomethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 3-(bromomethyl)-(123226-36-8)
• EPA Substance Registry System: Benzeneacetonitrile, 3-(bromomethyl)-(123226-36-8)

Safety Data

• Hazardous Substances Data: 123226-36-8(Hazardous Substances Data)

Upstream product

• 151-50-8 potassium cyanide 
• 2947-60-6 3-methylbenzyl cyanide 
• 177665-49-5 2-(3-(hydroxymethyl)phenyl)acetonitrile 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 

Downstream Products

• 177665-49-5 2-(3-(hydroxymethyl)phenyl)acetonitrile 
• 149492-32-0 3-hydroxymethylphenylacetic acid 
• 117706-53-3 [3-(4-Acetyl-2-allyl-5-hydroxy-phenoxymethyl)-phenyl]-acetonitrile 
• 861363-17-9 3-(3-cyanomethyl-phenyl)-propionic acid 
• 1256463-14-5 S-(3-cyanomethylphenyl)methylisothiourea hydrobromide 
• 1621326-09-7 C₂₈H₂₄OS 
• 1621326-11-1 C₃₆H₃₇NO₂S₃ 
• 1621326-13-3 C₄₀H₃₉N₃O₄S₃ 
• 1621326-15-5 C₆₀H₅₈N₄O₇S₃ 
• 1621326-17-7 C₄₄H₄₄N₄O₄S₃ 
• 1621325-88-9 C₂₅H₃₀N₄O₄S₃ 
• 1621326-08-6 C₂₈H₂₃NS 

Relevant articles and documents

Pd-catalyzed sp-sp3cross-coupling of benzyl bromides using lithium acetylides

Organolithium-based cross-coupling reactions have emerged as an indispensable method to construct C-C bonds. These transformations have proven particularly useful for the direct and fast coupling of various organolithium reagents (sp, sp2, and sp3) with aromatic (pseudo) halides (sp2). Here we present an efficient method for the cross-coupling of benzyl bromides (sp3) with lithium acetylides (sp). The reaction proceeds within 10 min at room temperature and can be performed in the presence of organolithium-sensitive functional groups such as esters, nitriles, amides and boronic esters. The potential application of the methodology is demonstrated in the preparation of key intermediates used in pharmaceuticals, chemical biology and natural products.

MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT

The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.

SUBSTITUTED PYRIDINONES

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.