1235765-33-9

Basic information

• Product Name: (2R,4R)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-dihydro-4-hydroxy-6-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-1(2H)-pyridinecarboxylic acid phenylmethyl ester
• Synonyms: (2R,4R)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-dihydro-4-hydroxy-6-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-1(2H)-pyridinecarboxylic acid phenylmethyl ester
• CAS NO: 1235765-33-9
• Molecular Weight: 591.979
• Mol File: 1235765-33-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4R)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-dihydro-4-hydroxy-6-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-1(2H)-pyridinecarboxylic acid phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-dihydro-4-hydroxy-6-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-1(2H)-pyridinecarboxylic acid phenylmethyl ester(1235765-33-9)
• EPA Substance Registry System: (2R,4R)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-dihydro-4-hydroxy-6-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-1(2H)-pyridinecarboxylic acid phenylmethyl ester(1235765-33-9)

Safety Data

• Hazardous Substances Data: 1235765-33-9(Hazardous Substances Data)

Upstream product

• 1190397-50-2 (2R)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-dihydro-6-[3-[[tris(1-methylethyl)silyl]oxy]propyl]-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester 

Relevant articles and documents

2,6-Disubstituted and 2,2,6-trisubstituted piperidines from serine: Asymmetric synthesis and further elaboration

(Figure presented) 4-Hydroxy-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl esters, which are readily prepared from serine and terminal acetylenes, undergo Claisen rearrangement to piperidine derivatives when heated with butyl vinyl ether in the presence of Hg(OAc)2 and Et3N. This route to optically pure piperidines having substituents α to nitrogen is general, and the rearrangement products are versatile intermediates for making a broad range of amines containing a substituted piperidine subunit.