1245013-80-2Relevant articles and documents
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
Cai, Jiaqiang,Baugh, Mark,Black, Darcey,Long, Clive,Jonathan Bennett,Dempster, Maureen,Fradera, Xavier,Gillespie, Jonathan,Andrews, Fiona,Boucharens, Sylviane,Bruin, John,Cameron, Kenneth S.,Cumming, Iain,Hamilton, William,Jones, Philip S.,Kaptein, Allard,Kinghorn, Emma,Maidment, Maurice,Martin, Iain,Mitchell, Ann,Rankovic, Zoran,Robinson, John,Scullion, Paul,Uitdehaag, Joost C.M.,Vink, Paul,Westwood, Paul,Van Zeeland, Mario,Van Berkom, Leon,Bastiani, Martijn,Meulemans, Tommi
scheme or table, p. 4350 - 4354 (2010/09/11)
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile analogues were identified as potent and selective cathepsin S inhibitor against both purified enzyme and in human JY cell based cellular assays. This core has a very stable thio-trapping nitrile war-head in comparison with the well reported pyrimidine-2-carbonitrile cysteine cathepsin inhibitors. Compound 47 is also very potent in in vivo mouse spleenic Lip10 accumulation assays.
