1245215-79-5

Basic information

• Product Name: 5-(4-chlorophenyl)-3-(4-nitrophenyl)-4,5-dihydro-1H-pyrazole
• Synonyms: 5-(4-chlorophenyl)-3-(4-nitrophenyl)-4,5-dihydro-1H-pyrazole
• CAS NO: 1245215-79-5
• Molecular Weight: 301.732
• Mol File: 1245215-79-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(4-chlorophenyl)-3-(4-nitrophenyl)-4,5-dihydro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)-3-(4-nitrophenyl)-4,5-dihydro-1H-pyrazole(1245215-79-5)
• EPA Substance Registry System: 5-(4-chlorophenyl)-3-(4-nitrophenyl)-4,5-dihydro-1H-pyrazole(1245215-79-5)

Safety Data

• Hazardous Substances Data: 1245215-79-5(Hazardous Substances Data)

Upstream product

• 25870-65-9 3-(4-chlorophenyl)-1-(4-nitrophenyl)-2-propen-1-one 
• 104-88-1 4-chlorobenzaldehyde 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 1245215-81-9 C₂₂H₁₆ClN₃O₃ 
• 1245216-12-9 C₁₇H₁₄ClN₃O₃ 

Relevant articles and documents

One-pot synthesis of 3,5-diphenyl-1h-pyrazoles from chalcones and hydrazine under mechanochemical ball milling

A highly efficient and environmentally friendly method has been developed for facile synthesis of 3,5-diphenyl-1H-pyrazoles under mechanochemical ball-milling conditions. The advantages of short reaction time, high efficiency, no separation of in situ generated intermediate, using cheap sodium persulfate as the oxidant, together with very simple work-up procedure, make this one-pot and solvent-free protocol a green and powerful alternative to traditional methods for the synthesis of these kinds of compounds.

Synthesis and antimicrobial activity of some pyrazoline derivatives

The objective of present study is to synthesize and screening of antimicrobial activity of some derivatives of pyrazoline. 1H-[4-nitro phenyl-5-(substituted phenyl)]pyrazoline has been used as a precursor to synthesize some biologically active heterocycles. Reaction of 1-(4-nitrophenyl)-3-(substituted phenyl) prop-2-en-1-one with hydrazine hydrate gave 1H-(3-nitrophenyl-5-(substituted phenyl) pyrazoline which on reaction with benzoyl chloride in pyridine gave 1-benzoyl-(4-nitrophenyl)-5-(substituted phenyl) prazoline and on reaction with acetic acid yields 1-acetyl-(4- nitrophenyl)-5-(substituted phenyl) pyrazoline derivatives. Several derivatives have been synthesized and screened for their antimicrobial efficacy against Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae. Antifungal activity against, Aspergillus flavus, Fusarium oxisporum, Aspergillus niger and Trichoderma viridae.