124655-06-7Relevant articles and documents
Total synthesis of (-)-bitungolide F
Su, Yingpeng,Xu, Yanfen,Han, Junjie,Zheng, Jiyue,Qi, Jing,Jiang, Tuo,Pan, Xinfu,She, Xuegong
supporting information; experimental part, p. 2743 - 2749 (2009/09/05)
An efficient total synthesis of (-)-bitungolide F (6) in 17 steps and 20.1% yield is described herein. Key steps involve a Myers asymmetric alkylation to introduce the C6 methyl with proper stereochemistry, a Claisen-like cyclization to construct the α,β-unsaturated β-lactone and a Julia-Kocienski olefination to assemble the conjugated diene moiety.
Optically active 3-demethylmevalonic acid derivatives, and intermediates
-
, (2008/06/13)
A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I STR1 (3,5-dihydroxy carboxylic acid derivatives) or of the formula II STR2 (β-hydroxy lactones) in which R, R1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII STR3 in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.