125620-16-8

Basic information

• Product Name: 3-(1H-TETRAZOL-1-YL)PHENOL
• Synonyms: 3-TETRAZOL-1-YL-PHENOL;3-(1H-TETRAZOL-1-YL)PHENOL;OTAVA-BB BB7020410033;3-(1H-Tetraazol-1-yl)phenol;3-(1,2,3,4-tetrazol-1-yl)phenol;3-(1-tetrazolyl)phenol
• CAS NO: 125620-16-8
• Molecular Formula: C₇H₆N₄O
• Molecular Weight: 162.15
• Mol File: 125620-16-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(1H-TETRAZOL-1-YL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-TETRAZOL-1-YL)PHENOL(125620-16-8)
• EPA Substance Registry System: 3-(1H-TETRAZOL-1-YL)PHENOL(125620-16-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 125620-16-8(Hazardous Substances Data)

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 591-27-5 m-Hydroxyaniline 
• 149-73-5 trimethyl orthoformate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 847606-85-3 2-(3-tetrazol-1-yl-phenoxy)-propionic acid methyl ester 
• 847606-84-2 N-[4-chloro-3-(trifluoromethyl)phenyl]-2-{[3-(1H-tetrazol-1-yl)phenyl]oxy}propanamide 
• 832739-85-2 2-(3-tetrazol-1-yl-phenoxy)-propionic acid 

Relevant articles and documents

Polymer-Supported Fe-Phthalocyanine Derived Heterogeneous Photo-Catalyst for the Synthesis of Tetrazoles Under Visible Light Irradiation

Abstract: Herein, a polymer supported Fe-Phthalocyanine entangled with carboxyl functionalized benzimidazolium moiety (PSFePcCFBM) explored as heterogenous photocatalyst, for regioselective synthesis of 1H-tetrazoles from sodium azide and other affordable

Design and biological evaluation of tetrahydropyridine derivatives as novel human GPR119 agonists

A series of novel tetrahydropyridine derivatives were prepared and evaluated using cell-based measurements. Systematic optimization of general structure G-1 led to the identification of compound 35 (EC50 = 4.9 nM) and 37 (EC50 = 8.8 nM) with high GPR119 agonism activity and moderate clog P. Through single and long-term pharmacodynamic experiments, we found that compound 35 showed a hypoglycemic effect and may have an effect on improving basal metabolic rate in DIO mice. Both in vitro and in vivo tests indicated that compound 35 was a potential potent GPR119 agonist in allusion to T2DM treatment.

Facile synthesis of 5-substituted-1H-tetrazoles and 1-substituted-1H- tetrazoles catalyzed by recyclable 4′-phenyl-2,2′:6′,2″- terpyridine copper(II) complex immobilized onto activated multi-walled carbon nanotubes

5-Substituted-1H-tetrazoles can conveniently be synthesized from the corresponding nitriles by reaction with NaN3 using the efficient and recyclable heterogeneous catalyst prepared by immobilization of copper(II) complex of 4′-phenyl-2,2′:6′,2″-terpyridine on activated multi-walled carbon nanotubes [AMWCNTs-O-Cu(II)-PhTPY]. Excellent results were obtained in each case affording the corresponding tetrazole adducts in good to excellent yields. In general, aromatic nitriles with electron-donating group could be accomplished as well as that with electron-withdrawing groups. By leaving out nitrile from the reaction and adding CH(OEt)3 and amines bearing various substituents, 1-substituted-1H-tetrazoles formed in water in high yields. The reported protocols have the advantages of rapid assembly of a host of heterocyclic systems in high yields with the added advantage of recycling and reuse of the catalyst.