1258958-20-1

Basic information

• Product Name: N-(4-methoxyphenyl)-N'-(5-phenyl-3-thienyl)thiourea
• Synonyms: N-(4-methoxyphenyl)-N'-(5-phenyl-3-thienyl)thiourea
• CAS NO: 1258958-20-1
• Molecular Weight: 340.47
• Mol File: 1258958-20-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-methoxyphenyl)-N'-(5-phenyl-3-thienyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-N'-(5-phenyl-3-thienyl)thiourea(1258958-20-1)
• EPA Substance Registry System: N-(4-methoxyphenyl)-N'-(5-phenyl-3-thienyl)thiourea(1258958-20-1)

Safety Data

• Hazardous Substances Data: 1258958-20-1(Hazardous Substances Data)

Upstream product

• 99972-47-1 3-amino-5-phenyl-2-thiophenecarboxylic acid 
• 75782-81-9 5-phenyl-3-thiopheneamine 
• 135137-14-3 3-isothiocyanato-5-phenylthiophene 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 1428907-37-2 N-(4-methoxyphenyl)-5-phenylthieno[3,2-d][1,3]thiazol-2-amine 
• 1258958-27-8 3-(4-methoxyphenyl)-2-[(5-phenyl-3-thienyl)imino]-1,3-thiazolidin-4-one 

Relevant articles and documents

Synthesis and biological evaluation of novel 2-heteroarylimino-1,3-thiazolidin-4-ones as potential anti-tumor agents

A series of 35 heteroarylimino-1,3-thiazolidinones with three sites of functionalization were synthesized and their antiproliferative properties were studied. The in vitro screening by MTT assay was performed against five cancer cell lines (human colon cancer cell lines HT29, HCT116 and SW620 and breast cancer cell lines MCF7 and MDA-MB-231). It was observed that N3-substituted thiazolidinones had moderate activities whereas 5-benzylidene thiazolidinones showed promising activities. To investigate the mechanism of action, detailed biological studies of six selected compounds (those presenting the lower mitotic index) were carried out on the human colon cancer HT29 cell line. Cell cycle assay revealed that those compounds induced cell accumulation in G2/M and in subG0/G1 phases of cell cycle. Moreover, dissipation of mitochondria membrane potential was observed as well as redox changes in treated cells.

Synthesis of novel N-substituted 2-(hetero)arylimino-1,3-thiazolidin-4-ones

The preparation of new N-substituted 2-arylimino-1,3-thiazolidin-4-ones from 5-substituted-3-aminothiophenes using an easy three-step procedure is described.