126216-67-9

Basic information

• Product Name: N-(2,6-Bis-benzotriazol-1-yl-piperidin-1-yl)-benzamide
• Synonyms: N-(2,6-Bis-benzotriazol-1-yl-piperidin-1-yl)-benzamide
• CAS NO: 126216-67-9
• Molecular Weight: 438.492
• Mol File: 126216-67-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2,6-Bis-benzotriazol-1-yl-piperidin-1-yl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,6-Bis-benzotriazol-1-yl-piperidin-1-yl)-benzamide(126216-67-9)
• EPA Substance Registry System: N-(2,6-Bis-benzotriazol-1-yl-piperidin-1-yl)-benzamide(126216-67-9)

Safety Data

• Hazardous Substances Data: 126216-67-9(Hazardous Substances Data)

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 613-94-5 benzoic acid hydrazide 
• 111-30-8 Glutaraldehyde 

Downstream Products

• 100875-43-2 2,6-dimethyl-N-(benzoylamino)piperidine 
• 126216-49-7 2,6-diphenyl-N-(benzoylamino)piperidine 
• 5454-07-9 N-3,4,5,6-tetrahydro-1(2H)-pyridinylbenzamide 

Relevant articles and documents

Benzotriazole: A novel synthetic auxiliary

Benzotriazole and aldehydes react reversibly to give addition products: in the presence of amines and other NH-compounds water can be eliminated to form products of type Bt-CHR-NR′R″. The latter are versatile intermediates for the preparation of primary, secondary, and tertiary amines and in the alkylation of hydroxylamines, hydrazines, amides, thioamides, and sulfonamides. Polyfunctional amines and other polyfunctional compounds can also be prepared, and they enable significant extending of Mannich reaction. Similar oxygen compounds Bt-CRR′-OR″ enable new syntheses of ethers and esters. Reactions in which benzotriazole is eliminated rather than substituted open up new pathways to enamines, enol ethers, and nitrones. The methodology is capable of extension to a variety of vinylogous systems including benzenoid and heteroaromatic derivatives. In addition to acting as a versatile leaving group, benzotriazolyl residues activate neighboring CH bonds to proton loss and a variety of such applications is described.