127946-77-4Relevant articles and documents
A 1 - amino - 1 - propionitrile hydrochloride synthetic method (by machine translation)
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Paragraph 0012; 0015, (2018/03/26)
The invention discloses a 1 - amino - 1 - propionitrile hydrochloride synthetic method, the method utilizes the amino acetonitrile as a starting material with benzene sulfonyl chloride reaction to obtain N, N - phenyl sulfonyl acetonitrile, continue to sodium hydride under alkaline conditions with 1, 2 - Dibromoethane ring reaction to obtain N, N - phenyl sulfonyl amino link propyl nitrile, finally removing benzoyl protection under the acidic condition to obtain the 1 - amino - 1 - propionitrile hydrochloride. The invention mild reaction conditions, high yield, low cost and is suitable for industrial application. (by machine translation)
HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
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Page/Page column 52, (2010/06/15)
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
DI-FLUORO CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
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Page/Page column 34-35, (2008/06/13)
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.