128269-65-8

Basic information

• Product Name: (2S,1'S)-2-Hydroxymethyl-N-1'-(2-methoxyphenyl)propyl-1-pyrrolidinecarboxamide
• Synonyms: (2S,1'S)-2-Hydroxymethyl-N-1'-(2-methoxyphenyl)propyl-1-pyrrolidinecarboxamide
• CAS NO: 128269-65-8
• Molecular Weight: 292.378
• Mol File: 128269-65-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,1'S)-2-Hydroxymethyl-N-1'-(2-methoxyphenyl)propyl-1-pyrrolidinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,1'S)-2-Hydroxymethyl-N-1'-(2-methoxyphenyl)propyl-1-pyrrolidinecarboxamide(128269-65-8)
• EPA Substance Registry System: (2S,1'S)-2-Hydroxymethyl-N-1'-(2-methoxyphenyl)propyl-1-pyrrolidinecarboxamide(128269-65-8)

Safety Data

• Hazardous Substances Data: 128269-65-8(Hazardous Substances Data)

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 128257-12-5 (3aS,6R)-6-(2-Methoxyphenyl)-5-oxa-7,8a-diazaperhydroazulen-8-one 
• 557-20-0 diethylzinc 
• 128257-10-3 (S)-1-carbamoyl-2-hydroxymethylpyrrolidine 
• 135-02-4 ortho-anisaldehyde 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Downstream Products

• 128257-16-9 (S)-N-Methyl-1-(2-methoxyphenyl)propylamine 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 

Relevant articles and documents

Asymmetric induction by chiral heterocyclic compounds: highly diastereoselective reaction of 5-oxa-7,8a-diazaperhydroazulen-8-ones with organometallic reagents

1) New chiral heterocyclic compounds, 5-oxa-7,8a-diazaperhydroazulen-8-ones (3a-c), were synthesized from (S)-prolinol (1) and potassium cyanate, followed by the condensation with aldehydes. 2) Extremely high diastereoselective reaction of the 3a-c with diethylzinc proceeded with a facil procedure to give (2S,1'S)-N-1'-arylpropyl-2-hydroxymethyl-1-pyrrolidinecarboxamide (4a-c). 3) The reduction of 4a-c with Red-Al gave (S)-1-aryl-N-methylpropylamines (5a-c) and (S)-prolinol (1) in good yields.