128277-66-7

Basic information

• Product Name: 2,3-dimethyl-4-methanesulfonyl-1-bromobenzene
• Synonyms: 2,3-dimethyl-4-methanesulfonyl-1-bromobenzene
• CAS NO: 128277-66-7
• Molecular Weight: 263.155
• Mol File: 128277-66-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2,3-dimethyl-4-methanesulfonyl-1-bromobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dimethyl-4-methanesulfonyl-1-bromobenzene(128277-66-7)
• EPA Substance Registry System: 2,3-dimethyl-4-methanesulfonyl-1-bromobenzene(128277-66-7)

Safety Data

• Hazardous Substances Data: 128277-66-7(Hazardous Substances Data)

Upstream product

• 66794-10-3 1,2-dimethyl-3-(methylsulfanyl)benzene 
• 87-59-2 2,3-Dimethylaniline 
• 250593-00-1 2,3-dimethyl-4-methylsulfanylbromobenzene 
• 22364-25-6 4-bromo-2,3-dimethylaniline 

Downstream Products

• 210631-68-8 topramezone 
• 247922-29-8 3-(3-bromo-2-methyl-6-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole 

Relevant articles and documents

The Synthesis and Crystal Structure of a Novel Pesticide Intermediates

A novel pesticide intermediates 3-(6-bromo-2-methyl-3-(methylsulfonyl)phenyl)-4,5-dihydroisoxazole was synthesized with 2,3-dimethylaniline as the starting materials. The final product and intermediates were characterized by mass spectra, 1H NMR, infrared and elemental analysis. The crystal structure of compounds 6 and 8 were determined by single crystal X-ray diffraction. Results shown that two oxazole compounds crystallize in the monoclinic (6) and triclinic (8) with the space group of P 21/c for 6 and P-1 for 8, respectively.

Preparation method of 3-[3-bromo-2-methyl-6-(methylsulfonyl) phenyl]-4, 5-dihydroisoxazole

The invention belongs to the field of chemical synthesis, the invention relates to a preparation method of 3-[3-bromo-2-methyl-6-(methylsulfonyl) phenyl]-4, 5 -dihydroisoxazole. The 3-[3-bromo-2-methyl-6-(methylsulfonyl) phenyl]-4, 5 -dihydroisoxazole is prepared by taking 2, 3-dimethylaniline as an initial raw material for reaction. The method comprises the following steps: diazotizing, brominating and oximating the 2, 3-dimethylaniline to obtain an oximated product, and is mainly characterized in that the oximated product is oxidized by a one-pot method, and then subjected to isoxazole cyclization to obtain the target product. The method has the advantages that monopoly of a traditional route is broken through in the last two steps, and the method is safe, environmentally friendly, easyto industrialize and promising in market prospect.

Preparation method of topramezone intermediate

The invention relates to a preparation method of a topramezone intermediate, which comprises the following steps: reacting 2,3-dimethyl diphenyl sulfide, hydrobromic acid and hydrogen peroxide in a solvent in the presence of a catalyst to obtain 2,3-dimet