1292283-69-2

Basic information

• Product Name: C₂₅H₃₈N₈O₆S₃
• Synonyms: C₂₅H₃₈N₈O₆S₃
• CAS NO: 1292283-69-2
• Molecular Weight: 642.825
• Mol File: 1292283-69-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₈N₈O₆S₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₈N₈O₆S₃(1292283-69-2)
• EPA Substance Registry System: C₂₅H₃₈N₈O₆S₃(1292283-69-2)

Safety Data

• Hazardous Substances Data: 1292283-69-2(Hazardous Substances Data)

Upstream product

• 890015-39-1 N,N-bis(2-thioethyl)glycine disulfide hydrochloride 
• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 104091-08-9 Fmoc-Glu(OtBu)-OH 
• 187618-60-6 N-α-[(9H-fluoren-9-ylmethoxy)carbonyl]-N^G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine 

Relevant articles and documents

Synthesis, in vitro screening and in vivo evaluation of cyclic RGD analogs cyclized through oxorhenium and oxotechnetium coordination

A library of RGD tripeptide analogs cyclized through oxorhenium coordination by an NS2/S chelation motif was synthesized. Screening towards integrins αVβ3, αIIbβ3 and αVβ5 led to the identification of 6 oxorhenium complexes that bind to integrin αVβ3 in the submicromolar range. In vivo evaluation of five of the corresponding oxotechnetium complexes using nude mice bearing a U87MG human tumor xenograft showed a significant and specific accumulation of radioactivity inside the tumor. The best results in vivo were obtained with complexes Tc-16 and Tc-50 that displayed a higher tumor accumulation and a lower distribution in other tissues relative to a reference cyclopentapeptide tracer.