1292308-95-2

Basic information

• Product Name: C₂₄H₂₈F₃NO₄*ClH
• CAS NO: 1292308-95-2
• Molecular Weight: 487.947
• Mol File: 1292308-95-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₈F₃NO₄*ClH(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₈F₃NO₄*ClH(1292308-95-2)
• EPA Substance Registry System: C₂₄H₂₈F₃NO₄*ClH(1292308-95-2)

Safety Data

• Hazardous Substances Data: 1292308-95-2(Hazardous Substances Data)

Upstream product

• 507276-74-6 Boc-D-Tyr(t-Bu)-OH 
• 1292308-92-9 C₂₃H₃₇NO₄ 
• 1246843-13-9 (R)-tert-butyl 3-(4-tert-butoxyphenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-yl(methyl)carbamate 
• 1246843-12-8 (R)-2-(tert-butoxycarbonyl(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid 

Relevant articles and documents

Unexpected stereochemical tolerance for the biological activity of tyroscherin

Here we describe the concise syntheses of the 15 diastereomers and key analogs of the natural product tyroscherin. While systematic analysis of the analogs clearly demonstrated that the hydrocarbon tail is important for biological activity, structure-activity relationship studies of the complete tyroscherin diastereoarray revealed a surprisingly expansive stereochemical tolerance for the cytotoxic activity. Our results represent a departure from the tenet that biological activity is constrained to a narrow pharmacophore, and highlight the recently emerging appreciation for stereochemical flexibility in defining the essential structural elements of biologically active small molecules.