1305317-31-0

Basic information

• Product Name: 8-bromo-2,3-diphenylpyrido[2,3-b]pyrazine
• Synonyms: 8-bromo-2,3-diphenylpyrido[2,3-b]pyrazine
• CAS NO: 1305317-31-0
• Molecular Weight: 362.228
• Mol File: 1305317-31-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-bromo-2,3-diphenylpyrido[2,3-b]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-bromo-2,3-diphenylpyrido[2,3-b]pyrazine(1305317-31-0)
• EPA Substance Registry System: 8-bromo-2,3-diphenylpyrido[2,3-b]pyrazine(1305317-31-0)

Safety Data

• Hazardous Substances Data: 1305317-31-0(Hazardous Substances Data)

Upstream product

• 13269-19-7 3-amino-2-nitropyridine 
• 1305317-30-9 3-amino-4-bromo-2-nitropyridine 
• 1232431-75-2 2,3-diamino-4-bromopyridine 
• 134-81-6 benzil 
• 1232-99-1 2,3-diphenylpyrido[3,2-b]pyrazine 

Downstream Products

• 1305317-33-2 8-azido-2,3-diphenylpyrido[2,3-b]pyrazine 
• 1305317-35-4 8-amino-2,3-diphenylpyrido[2,3-b]pyrazine 
• 1305317-37-6 N-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)-N'-ethylurea 
• 1305317-38-7 N-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)-N'-phenylurea 
• 1305317-39-8 N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)urea 
• 1305317-42-3 N-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)-N'-ethylthiourea 
• 1305317-43-4 N-(2,3-diphenylpyrido[2,3-b]pyrazin-8-yl)-N'-phenylthiourea 

Relevant articles and documents

From quinoxaline, pyrido[2,3-b]pyrazine and pyrido[3,4-b]pyrazine to pyrazino-fused carbazoles and carbolines

2,3-Diphenylated quinoxaline, pyrido[2,3-b]pyrazine and 8-bromopyrido[3,4-b]pyrazine were halogenated in deprotometalation-trapping reactions using mixed 2,2,6,6-tetramethyl piperidino-based lithium-zinc combinations in tetrahydrofuran. The 2,3-diphenylated 5-iodoquinoxaline, 8-iodopyrido[2,3-b]pyrazine and 8-bromo-7-iodopyrido[3,4-b]pyrazine thus obtained were subjected to palladium-catalyzed couplings with arylboronic acids or anilines, and possible subsequent cyclizations to afford the corresponding pyrazino[2,3-a]carbazole, pyrazino[2',3':5,6] pyrido[4,3-b]indole and pyrazino[2',3':4,5]pyrido[2,3-d]indole, respectively. 8-Iodopyrido[2,3-b] pyrazine was subjected either to a copper-catalyzed C-N bond formation with azoles, or to direct substitution to introduce alkylamino, benzylamino, hydrazine and aryloxy groups at the 8 position. The 8-hydrazino product was converted into aryl hydrazones. Most of the compounds were evaluated for their biological properties (antiproliferative activity in A2058 melanoma cells and disease-relevant kinase inhibition).