131086-78-7

Basic information

• Product Name: N¹,N⁵,N¹⁰-tri-<(E)-p-coumaroyl>-spermidine
• Synonyms: N¹,N⁵,N¹⁰-tri-<(E)-p-coumaroyl>-spermidine
• CAS NO: 131086-78-7
• Molecular Weight: 583.684
• Mol File: 131086-78-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 176-180 °C
• Boiling Point: 954.2±65.0 °C(Predicted)
• Density: 1.265±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N¹,N⁵,N¹⁰-tri-<(E)-p-coumaroyl>-spermidine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹,N⁵,N¹⁰-tri-<(E)-p-coumaroyl>-spermidine(131086-78-7)
• EPA Substance Registry System: N¹,N⁵,N¹⁰-tri-<(E)-p-coumaroyl>-spermidine(131086-78-7)

Safety Data

• Hazardous Substances Data: 131086-78-7(Hazardous Substances Data)

Usage

General Description

N1,N5,N10-tri-(E)-p-coumaroyl-spermidine is a naturally occurring polyamine derivative found in various plant species. It is composed of three molecules of p-coumaroyl groups attached to the spermidine backbone. N¹,N⁵,N¹⁰-tri-<(E)-p-coumaroyl>-spermidine has been identified as a phytochemical with potential antioxidant and anti-inflammatory properties. It has also been reported to exhibit cytotoxic activity against cancer cells. Additionally, N1,N5,N10-tri-(E)-p-coumaroyl-spermidine has been studied for its potential role in plant defense mechanisms and as a possible candidate for pharmacological applications. Overall, this chemical shows promise for further research and development in the fields of health and agriculture.

Upstream product

• 7400-08-0 p-Coumaric Acid 
• 124-20-9 N-(3-aminopropyl)-1,4-diaminobutane 
• 53901-95-4 p-acetoxycinnamoyl chloride 
• 134935-65-2 (E)-3-(4-<(methylsulfonyl)oxy>phenyl)prop-2-enoyl chloride 
• 182576-24-5 tert butyl (4 aminobutyl)(3-aminopropyl)carbamate 
• 334-50-9 spermidine trihydrochloride 
• 34446-64-5 (E)-3-(4-methoxyphenyl)propenoyl chloride 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 27542-85-4 4-acetoxycinnamic acid 
• 364048-97-5 N¹,N⁵,N¹⁰-tri(4-O-acetylcoumaroyl)spermidine 
• 131086-79-8 3-(4-methoxy-phenyl)-N-{4-[3-(4-methoxy-phenyl)-acryloylamino]-butyl}-N-{3-[3-(4-methoxy-phenyl)-acryloylamino]-propyl}-acrylamide 

Downstream Products

• 7400-08-0 p-Coumaric Acid 

Relevant articles and documents

The unusual conformational preference of N1,N5,N10-tri-p-coumaroylspermidine E-Z isomers from the Japanese apricot tree, Prunus mume, for the (ZZZ)-form

The Japanese apricot tree, Prunus mume (Siebold) Siebold & Zucc. cv. Nanko, bears two types of flowers: those with anthers that fluoresce under UV irradiation, and those that do not. The chemical composition of both types of anthers has been investigated:

A new nonpeptide tachykinin NK1 receptor antagonist isolated from the plants of compositae

To find new tachykinin NK1 receptor antagonists from natural sources, we examined the tachykinin antagonist activity in the extracts of approximately 200 species of plants by the use of isolated guinea pig ileum. As a result, we discovered a no

Synthesis of 13C-dilabeled 4-coumaroylspermidines

Five 13C-dilabeled constitution isomers of 4-coumaroylspermidines were prepared in nine to eleven steps: N1,4-di[(E)-4-coumaroyl]-(5,8- 13C2)spermidine (13b), N1-[(E)-4-coumaroyl]-(5,8-13C2)spermidine (17b), N1,8-di[(E)-4-coumaroyl]-(1,4-13C2)spermidine (20b), N4-[(E)-4- coumaroyl]-(1,4-13C2)spermidine (24b) and N1,4,8-tri[(E)-4-coumaroyl]- (5,8-13C2)spermidine (26). The two 13C-atoms were subsequently introduced using labeled potassium cyanide. The synthesis proceeds through stepwise construction of the polyamine backbone including protection and deprotection steps of the amino functions. Based on 1H-1H NOE interactions, the preliminary study of their binding reveals that 20b binds to tRNA in the same way as spermidine does, whereas 24b and 26 do not show any NOE effects with the tRNA protons.