13196-28-6

Basic information

• Product Name: AKOS B016267
• Synonyms: ART-CHEM-BB B016267;AKOS B016267;2-phenyl-1-(2-thienyl)ethanone;2-phenyl-1-thiophen-2-ylethanone;2-phenyl-1-thiophen-2-yl-ethanone
• CAS NO: 13196-28-6
• Molecular Formula: C₁₂H₁₀OS
• Molecular Weight: 202.27
• Mol File: 13196-28-6.mol
• Article Data: 28

Chemical Properties

• Melting Point: 44.5 °C
• Boiling Point: 179 °C(Press: 11 Torr)
• Appearance: /
• Density: 1.181±0.06 g/cm3(Predicted)
• CAS DataBase Reference: AKOS B016267(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS B016267(13196-28-6)
• EPA Substance Registry System: AKOS B016267(13196-28-6)

Safety Data

• Hazardous Substances Data: 13196-28-6(Hazardous Substances Data)

Usage

Description

AKOS B016267, also known as 4-Methoxy-6-methyl-1,3,5-triazine-2(1H)-thione, is a chemical compound that is a derivative of triazine and thione. It is used in various industrial applications and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical and Agrochemical Industries:
AKOS B016267 is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals for its potential applications in drug development and crop protection.
Used in Antimicrobial and Antiviral Applications:
AKOS B016267 is used as an antimicrobial and antiviral agent due to its reported properties, making it a potential candidate for the development of new drugs to combat infections and viral diseases.
Used in Dye and Pigment Industries:
AKOS B016267 is used as a building block in the production of dyes, pigments, and other specialty chemicals, contributing to the creation of various colorants and compounds for different industries.
Safety Precautions:
It is important to handle AKOS B016267 with caution as it may be harmful if swallowed, inhaled, or comes into contact with skin. Proper safety measures should be taken during its use and handling to minimize potential risks.

Upstream product

• 188290-36-0 thiophene 
• 103-80-0 phenylacetyl chloride 
• 98-03-3 thiophene-2-carbaldehyde 
• 908094-04-2 phenyldiazomethane 
• 88-15-3 2-Acetylthiophene 
• 591-50-4 iodobenzene 
• 98-86-2 acetophenone 
• 95092-10-7 N-methoxy-N-methyl-2-phenylacetamide 
• 5713-61-1 thiophen-2-yl magnesium bromide 
• 71-43-2 benzene 
• 62889-07-0 trimethyl((1-(thiophen-2-yl)vinyl)oxy)silane 
• 66003-76-7 Diphenyliodonium triflate 
• 1589-82-8 phenylmagnesium bromide 
• 6165-68-0 thiophene boronic acid 

Downstream Products

• 42291-11-2 α-(thien-2-yl)benzeneethanamine 
• 21075-48-9 3-phenyl-2-(thiophen-2-yl)-1H-indole 
• 101717-34-4 2-phenyl-1-[2]thienyl-ethanone-(2,4-dinitro-phenylhydrazone) 
• 28540-70-7 2-phenethylthiophene 
• 30135-07-0 1-phenyl-2-(2-thienyl)ethanedione 
• 194935-44-9 2-phenyl-1-[2]thienyl-butan-1-one 

Relevant articles and documents

Synthesis of 2-Phenyl-1-(2-thienyl)- and 2-Aryl-1-(2-furyl)ethanones by the SRN! Mechanism. Relative Reactivities of Enolate Ions of Ketones

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Keto - Enol interconversion of 2-phenylacetylthiophene

The equilibrium constant for keto-enol tautomerism of 2-phenylacetylthiophene (2PAT) KT = [enol]/ [ketone] has been determined as 3.55 × 10-7 (pKT 6.45) by combining rate constants for enolisation and ketonisation. The pK

An Oxidant- And Catalyst-Free Synthesis of Dibenzo[ a, c ]carbazoles via UV Light Irradiation of 2,3-Diphenyl-1 H -indoles

An efficient methodology for the synthesis of dibenzo[a,c]- carbazoles via annulation of 2,3-diphenyl-1H-indoles in EtOH under UV light irradiation (λO = 365 nm) along with hydrogen evolution is described. This method exhibits the advantages of mild reaction conditions, no requirement of any oxidants and catalysts, and release of hydrogen as the only byproduct. Notably, the mechanism investigation confirms that the trans-4b,8a-dihydro-9H-dibenzo[a,c]carbazole intermediate could convert into cis-4b,8a-dihydro-9H-dibenzo[a,c]carbazole, which relies on the nitrogen atom of the indole ring. This is followed by intramolecular dehydrogenation which yields the dibenzo[a,c]carbazoles. 2021. Thieme. All rights reserved.

Versatile and base-free copper-catalyzed α-arylations of aromatic ketones using diaryliodonium salts

A ligand and base-free copper catalyzed synthetic method for the efficient α-arylation of aromatic ketones is described. In order to avoid strong bases, ketone-derived silyl enol ethers were employed. Their reaction with diaryliodonium salts as aryl source provided the intermolecular C–C coupling displaying good functional group tolerance and requiring low catalyst loading.

A copper-catalyzed insertion of sulfur dioxide: Via radical coupling

A copper-catalyzed three-component reaction of O-acyl oximes, DABCO·(SO2)2, and 2H-azirines under mild conditions has been achieved. This protocol provides an efficient route for the construction of various tetrasubstituted β-sulfonyl N-unprotected enamines in moderate to good yields with excellent stereoselectivity and regioselectivity. Notably, this method represents a rare example of 2H-azirines as useful synthons for β-functionalized N-unprotected enamines. Preliminary mechanistic studies indicate that the reaction proceeds through coupling of a sulfonyl radical and α-carbon radical via copper-catalyzed ring-opening C-C bond cleavage of O-acyl oxime and C-N bond cleavage of 2H-azirine with the insertion of sulfur dioxide.